References

medgen

Медицинская генетика

Medical Genetics

2073-7998

Publishing House «Genius Media» LLC

10.25557/2073-7998.2018.07.3-10

medgen-527

Research Article

НАУЧНЫЕ ОБЗОРЫ

REVIEW

ГЕНЕТИЧЕСКИЕ ОСНОВЫ ОСТЕОПОРОЗА

GENETIC BASIS OF OSTEOPOROSIS

Миргалиева

Р. Я.

Mirgaliyeva

R. Ya.

reginchik55@rambler.ru

Хуснутдинова

Э. К.

Khusnutdinova

E. K.

reginchik55@rambler.ru

Хусайнова

Р. И.

Khusainova

R. I.

reginchik55@rambler.ru

Институт биохимии и генетики — обособленное структурное подразделение Федерального государственного бюджетного научного учреждения Уфимского федерального исследовательского центра Российской академии наук; ГБУЗ Республиканский медико-генетический центрРоссияInstitute of Biochemistry and Genetics — Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences; Republican Medical Genetic CenterRussian Federation

Институт биохимии и генетики — обособленное структурное подразделение Федерального государственного бюджетного научного учреждения Уфимского федерального исследовательского центра Российской академии наукРоссияInstitute of Biochemistry and Genetics — Subdivision of the Ufa Federal Research Centre of the Russian Academy of SciencesRussian Federation

2018

08102018

177310

2018

Миргалиева Р.Я., Хуснутдинова Э.К., Хусайнова Р.И.

Mirgaliyeva R.Y., Khusnutdinova E.K., Khusainova R.I.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.medgen-journal.ru/jour/article/view/527

Остеопороз (ОП) является одним из наиболее распространенных метаболических заболеваний скелета и одной из ведущих причин инвалидности и сокращения продолжительности жизни людей пожилого возраста, что делает его одной из важнейших проблем здравоохранения во всем мире. ОП — многофакторное заболевание, в развитии которого играют роль как генетические, так и средовые факторы риска. В настоящее время наблюдается значительный прогресс в изучении молекулярного патогенеза заболевания, однако исследования генетических основ ОП далеки от завершения. Знание эпидемиологии и понимание патогенеза ОП необходимы для разработки эффективных методов пресимптоматической диагностики, лечения и профилактики заболевания. Обзор посвящен систематизации результатов исследований генетических аспектов ОП и современным тенденциям дальнейшего изучения проблемы.

Osteoporosis (OP) is one of the most common metabolic diseases of the skeleton, the frequency of which rises with age. OP is one of the leading causes of disability and a reduction in life expectancy in the elderly, thereby dealing with one of the most important public health problems around the world. A major role in the development of OP play both gender and genetic factors, there are gender and regional differences in the prevalence of the disease. Currently, there has been significant progress in detecting the molecular pathogenesis of the disease, but studies of the genetic basis of OP are far from completion and there are many issues, which need further study. Understanding the epidemiology and pathogenesis of osteoporosis is necessary for the development of effective methods of presymptomatic diagnostics, treatment and prevention of diseases. The review is devoted to the systematization of the results of studies on the genetic aspects of OP and current trends in further study of the problem.

остеопорозостеопоретические переломыМПКТGWASRANK-RANKL-OPGПТГ

osteoporosisosteoporotic fracturesBMDGWASRANK-RANKL-OPG

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The authors declare that there are no conflicts of interest present.