References

medgen

Медицинская генетика

Medical Genetics

2073-7998

Publishing House «Genius Media» LLC

10.25557/2073-7998.2018.01.3-8

medgen-375

Research Article

НАУЧНЫЕ ОБЗОРЫ

REVIEW

Цитогенетические и экспрессионные маркеры индивидуальной радиочувствительности человека

Cytogenetic and expression markers of individual human radiosensitivity

Васильев

С. А.

Vasilyev

S. A.

genetics@tnimc.ru

Лебедев

И. Н.

Lebedev

I. N.

noemail@neicon.ru

ФГБНУ «Томский национальный исследовательский медицинский центр Российской академии наук»РоссияTomsk National Research Institute of Medical GeneticsRussian Federation

2018

26032018

17138

2018

Васильев С.А., Лебедев И.Н.

Vasilyev S.A., Lebedev I.N.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.medgen-journal.ru/jour/article/view/375

Воздействие ионизирующего излучения вызывает значительные функциональные изменения в клетках человека, выражающиеся в активации различных сигнальных путей и транскрипционного ответа множества генов. Величина этих изменений вариабельна у разных индивидов, составляя феномен индивидуальной радиочувствительности. В обзоре рассматриваются известные маркеры индивидуальной радиочувствительности человека, начиная от цитогенетических, позволяющих непосредственно оценить эффективность репарации радиационно-индуцированных повреждений ДНК в клетках, до маркеров, выделенных на основании полногеномных и полнотранскриптомных исследований дифференциально экспрессирующихся генов, обусловливающих различные аспекты клеточного и организменного ответа на радиационное воздействие.

Exposure to ionizing radiation causes significant functional changes in human cells which lead to activation of various signaling pathways and transcriptional response of many genes. The magnitude of these changes is variable for different individuals, making the phenomenon of individual radiosensitivity. In the review, markers of individual radiosensitivity are described ranging from cytogenetic markers for assessing the efficiency of DNA repair of radiation-induced damage in cells to genome- and transcriptome-wide approaches to identify differentially expressed genes that determine various aspects of response to radiation exposure.

биомаркерыиндивидуальная радиочувствительностьхромосомные аберрациимикроядрафокусы gH2AXэкспрессия геновbiomarkersindividual radiosensitivitychromosome aberrationsmicronucleigH2AX focigene expression

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The authors declare that there are no conflicts of interest present.