medgenМедицинская генетикаMedical Genetics2073-7998Publishing House «Genius Media» LLCmedgen-301Research ArticleНАУЧНЫЕ ОБЗОРЫREVIEWАссоциация полиморфизма гена опиоидных рецепторов OPRM1 с фенотипическим разнообразием хронического болевого синдрома онкологического генезаAssociation of opioid receptors gene OPRM1 polymorphism and phenotypic diversity of chronic pain syndrome of oncological genesisБоброваО. П.BobrovaO. P.bop_351971@mail.ruШнайдерН. А.ShnayderN. A.noemail@neicon.ruЗыряновС. К.ZyryanovS. K.noemail@neicon.ruМодестовА. А.ModestovA. A.noemail@neicon.ruФГБОУ ВО «Красноярский государственный медицинский университет им. проф. В.Ф. Войно-Ясенецкого» Минздрава России; КГБУЗ «Красноярский краевой клинический онкологический диспансер им. А.И. Крыжановского»РоссияKrasnoyarsk State Medical University named after Professor V.F. Voyno-Yasenetsky; Krasnoyarsk Regional Clinical Oncology Dispensary named after A.I. KryzhanovskyRussian FederationФГБОУ ВО «Красноярский государственный медицинский университет им. проф. В.Ф. Войно-Ясенецкого» Минздрава РоссииРоссияKrasnoyarsk State Medical University named after Professor V.F. Voyno-YasenetskyRussian FederationФГАОУ ВО Российский университет дружбы народовРоссияPeoples’ Friendship University of RussiaRussian Federation20172002201816638Copyright © Боброва О.П., Шнайдер Н.А., Зырянов С.К., Модестов А.А., 20182018Боброва О.П., Шнайдер Н.А., Зырянов С.К., Модестов А.А.Bobrova O.P., Shnayder N.A., Zyryanov S.K., Modestov A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medgen-journal.ru/jour/article/view/301

Авторами представлен обзор отечественной и зарубежной литературы, отражающий результаты современных исследований ассоциаций носительства однонуклеотидного полиморфизма OPRM1 гена опиоидных рецепторов, участвующих в перцепции боли и ответе на анальгетическую терапию. Сделан акцент на фенотипическом разнообразии хронического болевого синдрома у пациентов с онкопатологией.

The authors presented an overview of literature, which reflects the results of the recent studies of associations of carrying single nucleotide polymorphisms of the OPRM1 gene for opioid receptors involved in pain perception and response to analgesic therapy. The authors emphasized the phenotypic variability of chronic pain syndrome in patients with oncopathology.

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The authors declare that there are no conflicts of interest present.