Currently, as a result of the active processes of migration and assimilation, the transformation of the structure of the gene pools of the indigenous peoples of the world is being recorded, which in turn can lead to a change in the structure of morbidity. New data have been obtained regarding polymorphic variants of the vitamin D receptor genes VDR rs1544410, rs7968585, rs731236, rs2228570, rs3847987, rs79752 and vitamin-D binding protein GC rs7041, rs4588, rs375596 in local ethnic groups of Siberian Tatars in the Tomsk region. A specific genetic structure has been identified, characterized by polymorphic variants of genes encoding proteins with increased ability to bind and retain vitamin D in conditions of vitamin D deficiency.