<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medgen</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинская генетика</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Genetics</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2073-7998</issn><publisher><publisher-name>Publishing House «Genius Media» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.1234/XXXX-XXXX-2013-3-11-19</article-id><article-id custom-type="elpub" pub-id-type="custom">medgen-28</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НАУЧНЫЕ ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>ГЕНЕТИЧЕСКИЕ АСПЕКТЫ СУИЦИДАЛЬНОГО ПОВЕДЕНИЯ</article-title><trans-title-group xml:lang="en"><trans-title>GENETIC ASPECTS OF SUICIDAL BEHAVIOR</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зайнуллина</surname><given-names>А. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Zainullina</surname><given-names>A. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Уфа, 450054, пр. Октября, 71</p></bio><bio xml:lang="en"><p>Ufa, 450054, Pr. Oktyabrya, 71</p></bio><email xlink:type="simple">zainullina@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Халилова</surname><given-names>З. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Khalilova</surname><given-names>Z. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Уфа, 450054, пр. Октября, 71</p></bio><bio xml:lang="en"><p>Ufa, 450054, Pr. Oktyabrya, 71</p></bio><email xlink:type="simple">zainullina@bk.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хуснутдинова</surname><given-names>Э. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Khusnutdinova</surname><given-names>E. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Уфа, 450054, пр. Октября, 71</p><p>Уфа, 450000, ул. 3. Валиди, 32</p></bio><bio xml:lang="en"><p>Ufa, 450054, Pr. Oktyabrya, 71</p><p>Ufa, 450000, Z. Validi str</p></bio><email xlink:type="simple">zainullina@bk.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Институт биохимии и генетики Уфимского научного центра РАН</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Institute of Biochem istry and Genetics</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Институт биохимии и генетики Уфимского научного центра РАН,</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Institute of Biochem istry and Genetics</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Институт биохимии и генетики Уфимского научного центра РАН; Башкирский государственный университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Institute of Biochem istry and Genetics, Ufa Scientific Center of Russian Academy of Sciences;  Bashkir State University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>22</day><month>12</month><year>2015</year></pub-date><volume>12</volume><issue>3</issue><fpage>11</fpage><lpage>19</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Зайнуллина А.Г., Халилова З.Л., Хуснутдинова Э.К., 2015</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="ru">Зайнуллина А.Г., Халилова З.Л., Хуснутдинова Э.К.</copyright-holder><copyright-holder xml:lang="en">Zainullina A.G., Khalilova Z.L., Khusnutdinova E.K.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.medgen-journal.ru/jour/article/view/28">https://www.medgen-journal.ru/jour/article/view/28</self-uri><abstract><p>Суициды продолжают оставаться одной из наиболее острых медико-социальных проблем современности. Целью данной статьи был обзор отечественной и зарубежной научной литературы, посвящённой вопросам исследования генетической обусловленности суицидального поведения.</p><p> </p></abstract><trans-abstract xml:lang="en"><p>Suicides continue to be one of the most serious health and social prob I em of modern times. The aim of this article was to review national and foreign scientific literature on studies of genetic contribution in suicidal behavior.</p><p> </p></trans-abstract><kwd-group xml:lang="ru"><kwd>суицидальное поведение</kwd><kwd>стресс</kwd><kwd>молекулярная генетика</kwd><kwd>полногеномный анализ ассоциаций</kwd><kwd>эпигенетика</kwd></kwd-group><kwd-group xml:lang="en"><kwd>suicidal behavior</kwd><kwd>stress</kwd><kwd>molecular genetics</kwd><kwd>genome wide assotiation study</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Работа выполнена при финансовой поддержке гранта РГНФ (№11-06-00554а).</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Амахин Д.В., Веселкин Н.П. Взаимодействие эффектов нейромедиаторов глицина и ГАМК в центральной нервной системе // Цитология. — 2012. — №54 (6). — C. 469-477.</mixed-citation><mixed-citation xml:lang="en">Амахин Д.В., Веселкин Н.П. Взаимодействие эффектов нейромедиаторов глицина и ГАМК в центральной нервной системе // Цитология. — 2012. — №54 (6). — C. 469-477.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Валиахметов Р.М. Опыт социологического исследования проблемы суицида // Вестник общественного мнения: Данные. Анализ. Дискуссии / Аналитический центр Юрия Левады (Левада-Центр). Междисциплинарный академический центр социальных наук (Интерцентр). — 2010. — №1(103). — С. 65-89.</mixed-citation><mixed-citation xml:lang="en">Валиахметов Р.М. Опыт социологического исследования проблемы суицида // Вестник общественного мнения: Данные. Анализ. Дискуссии / Аналитический центр Юрия Левады (Левада-Центр). Междисциплинарный академический центр социальных наук (Интерцентр). — 2010. — №1(103). — С. 65-89.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Гайсина Д.А., Халилова З.Л., Хуснутдинова Э.К. Генетические факторы риска суицидального поведения //Журнал неврологии и психиатрии им. С.С. Корсакова. — 2008. — №1. — C. 87-91.</mixed-citation><mixed-citation xml:lang="en">Гайсина Д.А., Халилова З.Л., Хуснутдинова Э.К. Генетические факторы риска суицидального поведения //Журнал неврологии и психиатрии им. С.С. Корсакова. — 2008. — №1. — C. 87-91.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Литвиненко И.В., Одинак М.М. Патогенетические основы формирования когнитивных и психотических нарушений при болезни Паркинсона // Журнал Неврологии и Психиатрии. — 2004. — №4. — С. 72-76.</mixed-citation><mixed-citation xml:lang="en">Литвиненко И.В., Одинак М.М. Патогенетические основы формирования когнитивных и психотических нарушений при болезни Паркинсона // Журнал Неврологии и Психиатрии. — 2004. — №4. — С. 72-76.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Розанов В.А. О механизмах формирования суицидального поведения и возможностях его предикции на ранних этапах развития // Украинский медицинский журнал. — 2010. — Т. 1(75). — С. 92-97.</mixed-citation><mixed-citation xml:lang="en">Розанов В.А. О механизмах формирования суицидального поведения и возможностях его предикции на ранних этапах развития // Украинский медицинский журнал. — 2010. — Т. 1(75). — С. 92-97.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Тиходеев О.Н. Генетический контроль предрасположенности к самоубийству // Экологическая генетика. — 2007. — Т. 5(4). — С. 22-43.</mixed-citation><mixed-citation xml:lang="en">Тиходеев О.Н. Генетический контроль предрасположенности к самоубийству // Экологическая генетика. — 2007. — Т. 5(4). — С. 22-43.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Bardi M., Huff man M.A. Effects of maternal styl e on inf ant behavior in Japanese macaques (Macaca fuscata) // Dev. Psychobiol. — 2002. — Vol. 41(4). — P. 364-372.</mixed-citation><mixed-citation xml:lang="en">Bardi M., Huff man M.A. Effects of maternal styl e on inf ant behavior in Japanese macaques (Macaca fuscata) // Dev. Psychobiol. — 2002. — Vol. 41(4). — P. 364-372.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Binder E. The rol e of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders // Psychoneuroendocrinology. — 2009. — Vol. 34S. — P. S186-S195.</mixed-citation><mixed-citation xml:lang="en">Binder E. The rol e of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders // Psychoneuroendocrinology. — 2009. — Vol. 34S. — P. S186-S195.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Boscarino J., Erlich P., Hoffman S., Zhang X. Higher FKBP5, COMT, CHRNA5, and CRHR1 allele burdens are associated with PTSD and interact with trauma exposure: implications for neuropsychiatric research and treatment // Neuropsychiatric Disease and Treatment. — 2012. — Vol. 8. — P. 131-139.</mixed-citation><mixed-citation xml:lang="en">Boscarino J., Erlich P., Hoffman S., Zhang X. Higher FKBP5, COMT, CHRNA5, and CRHR1 allele burdens are associated with PTSD and interact with trauma exposure: implications for neuropsychiatric research and treatment // Neuropsychiatric Disease and Treatment. — 2012. — Vol. 8. — P. 131-139.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Brent D., Melhem N., Ferrell R. et al. Association of FKBP5 Polymorphisms With Suicidal Events in the Treatment of Resistant Depression in Adolescents (TORDIA) Study // Am. J. Psychiatry. — 2010. — Vol. 167(2). — P. 190-197.</mixed-citation><mixed-citation xml:lang="en">Brent D., Melhem N., Ferrell R. et al. Association of FKBP5 Polymorphisms With Suicidal Events in the Treatment of Resistant Depression in Adolescents (TORDIA) Study // Am. J. Psychiatry. — 2010. — Vol. 167(2). — P. 190-197.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Brezo J., Bureau A., Mеrette C. et al. Differences and similarities in the serotonergic diathesis for suicide attempts and mood disorders: a 22-year longitudinal gene-environment study // Mol. Psychiatry. — 2010. — Vol. 15(8). — P. 831-843.</mixed-citation><mixed-citation xml:lang="en">Brezo J., Bureau A., Mеrette C. et al. Differences and similarities in the serotonergic diathesis for suicide attempts and mood disorders: a 22-year longitudinal gene-environment study // Mol. Psychiatry. — 2010. — Vol. 15(8). — P. 831-843.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Cannon D., Klaver J., Gandhi S. et al. Genetic variation in cholinergic muscarinic-2 receptor gene modulates M2 receptor binding in vivo and accounts for reduced binding in bipolar disorder // Mol Psychiatry. — 2011. — Vol. 16(4). — P. 407-418.</mixed-citation><mixed-citation xml:lang="en">Cannon D., Klaver J., Gandhi S. et al. Genetic variation in cholinergic muscarinic-2 receptor gene modulates M2 receptor binding in vivo and accounts for reduced binding in bipolar disorder // Mol Psychiatry. — 2011. — Vol. 16(4). — P. 407-418.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Chen T., Blum K., Mathews D. et al. Are dopaminergic genes involved in a predisposition to pathological aggression? Hypothesizing the importance of «super normal controls» in psychiatricge-netic research of complex behavioral disorders // Med Hypotheses. — 2005. — Vol. 65. — P. 703-707.</mixed-citation><mixed-citation xml:lang="en">Chen T., Blum K., Mathews D. et al. Are dopaminergic genes involved in a predisposition to pathological aggression? Hypothesizing the importance of «super normal controls» in psychiatricge-netic research of complex behavioral disorders // Med Hypotheses. — 2005. — Vol. 65. — P. 703-707.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Cohen-Woods S., Gaysina D., Craddock N. et al. Depression Case Control (DeCC) Study fa-ls to support involvement of the muscarinic acetylcholine receptor M2 (CHRM2) gene in recurrent maj or depressive disorder // Hum. Mol. Genet. — 2009. — Vol. 18(8). — P. 1504-1509.</mixed-citation><mixed-citation xml:lang="en">Cohen-Woods S., Gaysina D., Craddock N. et al. Depression Case Control (DeCC) Study fa-ls to support involvement of the muscarinic acetylcholine receptor M2 (CHRM2) gene in recurrent maj or depressive disorder // Hum. Mol. Genet. — 2009. — Vol. 18(8). — P. 1504-1509.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">De Luca V., Strauss J., Kennedy J. Power based association analysis (PBAT) of serotonergic and noradrenergic polymorphisms in bipolar patients with suicidal behavior // Prog. Neuropsychophar-macol. Biol. Psychiatry. — 2008. — Vol. 32(1). — P. 197-203.</mixed-citation><mixed-citation xml:lang="en">De Luca V., Strauss J., Kennedy J. Power based association analysis (PBAT) of serotonergic and noradrenergic polymorphisms in bipolar patients with suicidal behavior // Prog. Neuropsychophar-macol. Biol. Psychiatry. — 2008. — Vol. 32(1). — P. 197-203.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">De Luca V., Tharma-ingam S., Zai C. et al. Association of HPA axis genes with suicideal behavior in schizophrenia // J. Psyc-hopharmacol. (Oxford). — 2010. — Vol. 24. — P. 677-682.</mixed-citation><mixed-citation xml:lang="en">De Luca V., Tharma-ingam S., Zai C. et al. Association of HPA axis genes with suicideal behavior in schizophrenia // J. Psyc-hopharmacol. (Oxford). — 2010. — Vol. 24. — P. 677-682.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Fiori L.M., Zouk H., Himmelman C., Turecki G. X chromosome and suicide // Molecular Psychiatry. — 2011. — Vol. 16. — P. 216-226.</mixed-citation><mixed-citation xml:lang="en">Fiori L.M., Zouk H., Himmelman C., Turecki G. X chromosome and suicide // Molecular Psychiatry. — 2011. — Vol. 16. — P. 216-226.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Gal3avy H., Zalsman G., Yu Y. et al. A pi-ot genome wide association and gene expression array study of suicide with and without major depression // The World Journal of Biological Psychiatry. — 2011. Ear-y Online. doi: 10.3109/15622975.2011.597875. — P.1-9.</mixed-citation><mixed-citation xml:lang="en">Gal3avy H., Zalsman G., Yu Y. et al. A pi-ot genome wide association and gene expression array study of suicide with and without major depression // The World Journal of Biological Psychiatry. — 2011. Ear-y Online. doi: 10.3109/15622975.2011.597875. — P.1-9.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Gaysina D., Zainullina A., Khusnutdinova E. Inherited Neuropsychiatric Disorders in Russia // Genomics and Health in the Developing World (Ed. by Kumar D.). — 2012. — Vol. 62. — P. 1356-1367.</mixed-citation><mixed-citation xml:lang="en">Gaysina D., Zainullina A., Khusnutdinova E. Inherited Neuropsychiatric Disorders in Russia // Genomics and Health in the Developing World (Ed. by Kumar D.). — 2012. — Vol. 62. — P. 1356-1367.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Ikeda M., Hikita T., Taya S. et al. Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia // Human Molecular Genetics. — 2008. — Vol. 17(20). — P. 3212-3222.</mixed-citation><mixed-citation xml:lang="en">Ikeda M., Hikita T., Taya S. et al. Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia // Human Molecular Genetics. — 2008. — Vol. 17(20). — P. 3212-3222.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Jia P., Wang L., Fanous A.H. et al. Network-assisted investigation of combined causal signals from genome-wide association studies in schizophrenia // PLoS Comput Biol. — 2012. — Vol. 8(7). e1002587. doi: 10.1371/journal.pcbi.1002587.</mixed-citation><mixed-citation xml:lang="en">Jia P., Wang L., Fanous A.H. et al. Network-assisted investigation of combined causal signals from genome-wide association studies in schizophrenia // PLoS Comput Biol. — 2012. — Vol. 8(7). e1002587. doi: 10.1371/journal.pcbi.1002587.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Keck M., Kern N., Erhardt A. et al. combined effects of exonic polymorphisms in CRHR1 and AVPR1B genes in a case/con3rol study for panic disorder // American Journal of Medical Genetics Part И (Neuropsychiatry Genetics). — 2008. — Vol. 147B. — P. 1196-1204.</mixed-citation><mixed-citation xml:lang="en">Keck M., Kern N., Erhardt A. et al. combined effects of exonic polymorphisms in CRHR1 and AVPR1B genes in a case/con3rol study for panic disorder // American Journal of Medical Genetics Part И (Neuropsychiatry Genetics). — 2008. — Vol. 147B. — P. 1196-1204.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Linkowska K., Daca P., Sykutera M. et al. Search for association between suicide and 5-HTT, MAOA and DAT polymorphism in Polish males // Arch. Med. Sadowej Kryminol. — 2010. — Vol. 60(2-3). — P. 112-117.</mixed-citation><mixed-citation xml:lang="en">Linkowska K., Daca P., Sykutera M. et al. Search for association between suicide and 5-HTT, MAOA and DAT polymorphism in Polish males // Arch. Med. Sadowej Kryminol. — 2010. — Vol. 60(2-3). — P. 112-117.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Mann J., Brent D., Arango V. The neurobiology and genetics of suicide and attempted suicide: a focus on the serotonergic system // Neuropsychopharmacology. — 2001. — Vol. 24. — P. 467-477.</mixed-citation><mixed-citation xml:lang="en">Mann J., Brent D., Arango V. The neurobiology and genetics of suicide and attempted suicide: a focus on the serotonergic system // Neuropsychopharmacology. — 2001. — Vol. 24. — P. 467-477.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Mann J. Neurobiology of suicidal behavior // Nat. Rev. Ne-urosci. — 2003. — Vol. 4(10). — P. 819-828.</mixed-citation><mixed-citation xml:lang="en">Mann J. Neurobiology of suicidal behavior // Nat. Rev. Ne-urosci. — 2003. — Vol. 4(10). — P. 819-828.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Menke A., Domschke K., Czamara D. et al. Genome-Wide Association Study of Antidepressant Treatment-Emergent Suicidal Ideation // Neuropsychopharmacology. — 2012. — Vol. 37. — P. 797-807.</mixed-citation><mixed-citation xml:lang="en">Menke A., Domschke K., Czamara D. et al. Genome-Wide Association Study of Antidepressant Treatment-Emergent Suicidal Ideation // Neuropsychopharmacology. — 2012. — Vol. 37. — P. 797-807.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Neves F., Malloy-Diniz L., Romano-Silva M. et al. The role of BDNF genetic polymorphisms in bipolar disorder with psychiatric comorbidi-ies // J. Af-ect. Di-ord. — 2011. — Vol. 131(1-3). — P. 307-311.</mixed-citation><mixed-citation xml:lang="en">Neves F., Malloy-Diniz L., Romano-Silva M. et al. The role of BDNF genetic polymorphisms in bipolar disorder with psychiatric comorbidi-ies // J. Af-ect. Di-ord. — 2011. — Vol. 131(1-3). — P. 307-311.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Papiol S., Arias B., Gasto C. et al. Genetic variability at HPA axis in major depression and clinical response to antidepressant treatment // Journal of Afec-ive Disorders. — 2007. — Vol. 104. — P. 83-90.</mixed-citation><mixed-citation xml:lang="en">Papiol S., Arias B., Gasto C. et al. Genetic variability at HPA axis in major depression and clinical response to antidepressant treatment // Journal of Afec-ive Disorders. — 2007. — Vol. 104. — P. 83-90.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Perlis R. H., Huang J., Purcell S. et al. Genome-Wide Association Study of Suicide Attempts in Mood Disorder Patients // Am. J. Psychiatry. — 2010. — Vol. 167. — P.1499-1507.</mixed-citation><mixed-citation xml:lang="en">Perlis R. H., Huang J., Purcell S. et al. Genome-Wide Association Study of Suicide Attempts in Mood Disorder Patients // Am. J. Psychiatry. — 2010. — Vol. 167. — P.1499-1507.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Perroud N., Uher R., Ng M.Y. et al. Genome-wide association study of increasing suicidal ideation during antidepressant treatment in the GENDEP proj ect // The Pharmacogenomics Journal. — 2012. — Vol. 12. — P. 68-77.</mixed-citation><mixed-citation xml:lang="en">Perroud N., Uher R., Ng M.Y. et al. Genome-wide association study of increasing suicidal ideation during antidepressant treatment in the GENDEP proj ect // The Pharmacogenomics Journal. — 2012. — Vol. 12. — P. 68-77.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Pivac N., Pregelj P., Niko-ac M. et al. The association between catechol-O-methyl-transferase Val108/158Met polymorphism and suicide // Genes Brain Behav. — 2011. — Vol. 10(5). — P. 565-569.</mixed-citation><mixed-citation xml:lang="en">Pivac N., Pregelj P., Niko-ac M. et al. The association between catechol-O-methyl-transferase Val108/158Met polymorphism and suicide // Genes Brain Behav. — 2011. — Vol. 10(5). — P. 565-569.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Pregelj P., Nedic G., Paska A. et al. The association between brain-derived neurotrophic factor polymorphism (BDNF Val66Met) and suicide // J. Affect. Disord. — 2011. — Vol. 128(3). — P. 287-290.</mixed-citation><mixed-citation xml:lang="en">Pregelj P., Nedic G., Paska A. et al. The association between brain-derived neurotrophic factor polymorphism (BDNF Val66Met) and suicide // J. Affect. Disord. — 2011. — Vol. 128(3). — P. 287-290.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Roy A., Hodgkinson C., De Luca V. Two HPA axis genes, CRHBP and FKBP5, interact with childhood trauma to increase the risk for suicidal behavior // Journal of Psychiatric Research. — 2012. — Vol. 46. — P. 72-79.</mixed-citation><mixed-citation xml:lang="en">Roy A., Hodgkinson C., De Luca V. Two HPA axis genes, CRHBP and FKBP5, interact with childhood trauma to increase the risk for suicidal behavior // Journal of Psychiatric Research. — 2012. — Vol. 46. — P. 72-79.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Schosser A., Butler A.W., Ising M. et al. Genomewide Association Scan of Suicidal Thoughts and Behaviour in Major Depression // PLoS ONE. — 2011. — Vol. 6 (7). — e20690.</mixed-citation><mixed-citation xml:lang="en">Schosser A., Butler A.W., Ising M. et al. Genomewide Association Scan of Suicidal Thoughts and Behaviour in Major Depression // PLoS ONE. — 2011. — Vol. 6 (7). — e20690.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Sekiguchi H., Iritani S., Habuchi C. et al. Impairment of the tyrosine hydroxylase neuronal network in the orbitofrontal cortex of a genetically modified mouse model of schizophrenia // Brain Research. — 2011. — Vol. 1392. — P. 47-53.</mixed-citation><mixed-citation xml:lang="en">Sekiguchi H., Iritani S., Habuchi C. et al. Impairment of the tyrosine hydroxylase neuronal network in the orbitofrontal cortex of a genetically modified mouse model of schizophrenia // Brain Research. — 2011. — Vol. 1392. — P. 47-53.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Sequeira A., Mamdani F., Ernst C. et al. Global bram gene expression analysis links glutamatergic and GABAergic alterations to suicide and major depression // PLoS One. — 2009. — Vol. 4(8). — e6585.</mixed-citation><mixed-citation xml:lang="en">Sequeira A., Mamdani F., Ernst C. et al. Global bram gene expression analysis links glutamatergic and GABAergic alterations to suicide and major depression // PLoS One. — 2009. — Vol. 4(8). — e6585.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Serretti A., Calati R., Giegling I. et al. Serotonin receptor HTR1A and HTR2C variants and personality traits in suicide attem-p-ers and con-rols // J. Psychiatr. Res. — 2009. — Vol. 43(5). — P. 519-525.</mixed-citation><mixed-citation xml:lang="en">Serretti A., Calati R., Giegling I. et al. Serotonin receptor HTR1A and HTR2C variants and personality traits in suicide attem-p-ers and con-rols // J. Psychiatr. Res. — 2009. — Vol. 43(5). — P. 519-525.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Sher L. Dopamine and the pathophysiology of suicidal behavior in alcoholism // Med. Hypotheses. — 2006. — Vol. 66(5). — P. 1043-1044.</mixed-citation><mixed-citation xml:lang="en">Sher L. Dopamine and the pathophysiology of suicidal behavior in alcoholism // Med. Hypotheses. — 2006. — Vol. 66(5). — P. 1043-1044.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Sokolowski M., Ben-Efraim Y., Wasserman J, Wasser-man D. Glutamatergic GRIN2B and polyaminergic ODC1 genes in suicide attempts: associations and gene-environment interactions with childhood/adolescent physical assault // Mol. Psychiatry. — 2012. doi: 10.1038/mp.2012.112.</mixed-citation><mixed-citation xml:lang="en">Sokolowski M., Ben-Efraim Y., Wasserman J, Wasser-man D. Glutamatergic GRIN2B and polyaminergic ODC1 genes in suicide attempts: associations and gene-environment interactions with childhood/adolescent physical assault // Mol. Psychiatry. — 2012. doi: 10.1038/mp.2012.112.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Suda A., Kawanishi C., Kishida I. et al. Dopamine D2 recep-or gene polymorphisms are associated with suicide attempt in the Japanese population//Neuropsychobiology. — 2009. — Vol. 59(2). — P. 130-134.</mixed-citation><mixed-citation xml:lang="en">Suda A., Kawanishi C., Kishida I. et al. Dopamine D2 recep-or gene polymorphisms are associated with suicide attempt in the Japanese population//Neuropsychobiology. — 2009. — Vol. 59(2). — P. 130-134.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Tatro E.T., Nguyen T.B., Bousman C.A. Correlation of major depressive disorder symptoms with FKBP5 but not FKBP4 expression in human immunodeficiency virus-infected individuals // J. Neurovirol. — 2010. — Vol. 16(5). — P. 399-404.</mixed-citation><mixed-citation xml:lang="en">Tatro E.T., Nguyen T.B., Bousman C.A. Correlation of major depressive disorder symptoms with FKBP5 but not FKBP4 expression in human immunodeficiency virus-infected individuals // J. Neurovirol. — 2010. — Vol. 16(5). — P. 399-404.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Videtic A., Peternelj T., Zupanc T. et al. Promoter and functional polymorphisms of HTR2C and suicide victims // Genes Brain Behav. — 2009. — Vol. 8(5). — P. 541-555.</mixed-citation><mixed-citation xml:lang="en">Videtic A., Peternelj T., Zupanc T. et al. Promoter and functional polymorphisms of HTR2C and suicide victims // Genes Brain Behav. — 2009. — Vol. 8(5). — P. 541-555.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Videtic A., Zupanc T., Pregelj P. et al. Suicide, stress and serotonin receptor 1A promoter polymorphism -1019C&gt;G in Slovenian suicide victims // Eur. Arch. Psychiatry Clin. Neurosci. — 2009. — Vol. 259(4). — P. 234-238.</mixed-citation><mixed-citation xml:lang="en">Videtic A., Zupanc T., Pregelj P. et al. Suicide, stress and serotonin receptor 1A promoter polymorphism -1019C&gt;G in Slovenian suicide victims // Eur. Arch. Psychiatry Clin. Neurosci. — 2009. — Vol. 259(4). — P. 234-238.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Wasserman D. (Ed.) Suicide. An unnecessary death // Martin Dunitz, London. — 2001. — P. 287.</mixed-citation><mixed-citation xml:lang="en">Wasserman D. (Ed.) Suicide. An unnecessary death // Martin Dunitz, London. — 2001. — P. 287.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Wasserman D., Wasserman J., Rozanov V., Sokolowski M. depression in suicidal males: genetic risk variants in the CRHR1 gene // Genes, Brai n and Behavior. — 2009. — Vol. 8. — P. 72-77.</mixed-citation><mixed-citation xml:lang="en">Wasserman D., Wasserman J., Rozanov V., Sokolowski M. depression in suicidal males: genetic risk variants in the CRHR1 gene // Genes, Brai n and Behavior. — 2009. — Vol. 8. — P. 72-77.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Willour V., Chen H., Toolan J. et al. Family-based association of FKBP5 in bipolar disorder // Molecular psychiatry. — 2009. — Vol. 14. — P. 261-268.</mixed-citation><mixed-citation xml:lang="en">Willour V., Chen H., Toolan J. et al. Family-based association of FKBP5 in bipolar disorder // Molecular psychiatry. — 2009. — Vol. 14. — P. 261-268.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Yanagi M., Shirakawa O., Kitamura N. et al. Association of 14-3-3 gene haplotype with completed suicide in Japanese // J. Hum. Genet. — 2005. — Vol. 50. — P. 210-216.</mixed-citation><mixed-citation xml:lang="en">Yanagi M., Shirakawa O., Kitamura N. et al. Association of 14-3-3 gene haplotype with completed suicide in Japanese // J. Hum. Genet. — 2005. — Vol. 50. — P. 210-216.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Za-sman G., Patya M., Frisch A. et al. Association of polymorphisms of the serotonergic pathways with clinical traits of impul-sive-aggression and suicidality in adolescents: a multi-center study // World J. Biol. Psychiatry. — 2011. — Vol. 12(1). — P. 33-41.</mixed-citation><mixed-citation xml:lang="en">Za-sman G., Patya M., Frisch A. et al. Association of polymorphisms of the serotonergic pathways with clinical traits of impul-sive-aggression and suicidality in adolescents: a multi-center study // World J. Biol. Psychiatry. — 2011. — Vol. 12(1). — P. 33-41.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Zubenko G., Maher B., Hughes H. et al. Genome-wide linkage survey for genetic loci that affect the risk of suicide attempts in families with recurrent, ear-y-onset, maj or depression // Am. J. Med. Genet. B Neuropsychiatr. Genet. — 2004. — Vol. 129(1). — P. 47-54.</mixed-citation><mixed-citation xml:lang="en">Zubenko G., Maher B., Hughes H. et al. Genome-wide linkage survey for genetic loci that affect the risk of suicide attempts in families with recurrent, ear-y-onset, maj or depression // Am. J. Med. Genet. B Neuropsychiatr. Genet. — 2004. — Vol. 129(1). — P. 47-54.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Zupanc T., Pregelj P., Tomori M. et al. No association between polymorphisms in four serotonin receptor genes, serotonin transporter gene and alcohol-related suicide // Psychiatr. Danub. — 2010. — Vol. 22(4). — P. 522-527.</mixed-citation><mixed-citation xml:lang="en">Zupanc T., Pregelj P., Tomori M. et al. No association between polymorphisms in four serotonin receptor genes, serotonin transporter gene and alcohol-related suicide // Psychiatr. Danub. — 2010. — Vol. 22(4). — P. 522-527.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
