medgenМедицинская генетикаMedical Genetics2073-7998Publishing House «Genius Media» LLC10.1234/XXXX-XXXX-2013-3-3-10medgen-27Research ArticleНАУЧНЫЕ ОБЗОРЫREVIEWСОВРЕМЕННЫЕ ПРЕДСТАВЛЕНИЯ О ПАТОГЕНЕЗЕ И ГЕНЕТИКЕ ОСТЕОАРТРИТАMODERN VIEWS ON THE PATHOGENESIS AND GENETICS OF OSTEOARTHRITISТюринА. В.TyurinA. V.

г.Уфа, ул. Ленина, 3; 450000

anton.bgmu@gmail.comХусайноваР. И.KhusainovaR. I.

г.Уфа, пр. Октября, 71; 450054

ДавлетшинР. А.DavletshinR. A.

г.Уфа, ул. Ленина, 3; 450000

anton.bgmu@gmail.comХуснутдиноваЭ. К.KhusnutdinovaE. K.

г.Уфа, ул. Ленина, 3; 450000

Государственное бюджетное образовательное учреждение высшего профессионального образования Министерства здравоохранения России Башкирский государственный медицинский университетРоссияBashkir State Med i cal University, Ufa, Lenin street, 3Russian FederationФедеральное государственное бюджетное учреждение науки Институт биохимии и генетики УНЦ РАНРоссияInstitute of Biochem i stry and GeneticsRussian FederationГосударственное бюджетное образовательное учреждение высшего профессионального образования Министерства здравоохранения России Башкирский государственный медицинский университетРоссияBashkir State Med i cal UniversityRussian Federation201322122015123310Copyright © Тюрин А.В., Хусайнова Р.И., Давлетшин Р.А., Хуснутдинова Э.К., 20152015Тюрин А.В., Хусайнова Р.И., Давлетшин Р.А., Хуснутдинова Э.К.Tyurin A.V., Khusainova R.I., Davletshin R.A., Khusnutdinova E.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medgen-journal.ru/jour/article/view/27

Остеоартрит (osteoarthritis, М15-М19) — заболевание различной этиологии с характерными биологическими, морфологическими и клиническими проявлениями, в основе которых лежит поражение всех компонентов сустава — хряща, субхондральной кости, синовиальной оболочки, связок, капсулы околосуставных мышц. Этиология данного заболевания окончательно не установлена. По результатам исследований последних лет, все большая роль в патогенезе остеоартрита отводится генетической составляющей. В данном обзоре отражены результаты основных достижений и тенденций в области генетики остеоартрита, а также исследований роли эпигенетических факторов в развитии заболевания.

 

 

 

 

 

Osteoarthritis (M15-M19) — a disease of varying etiology with specific biological, morphological and clinical characteristics, which are based on damage of all components of the joint — the cartil age, subchondral bone, synovium, ligaments, periarticular muscles capsules. The etiology of this disease has not been established. According to the results of studies in recent years, an increasing role in the pathogenesis of osteoarthritis is given to genetic component. In this review the major achievements and trends in the field of ge-netl cs of osteoarthritis, as well as stud l es of epigenetic factors in the development of the disease are highl ighted.

 

 

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The authors declare that there are no conflicts of interest present.