medgenМедицинская генетикаMedical Genetics2073-7998Publishing House «Genius Media» LLCmedgen-263Research ArticleНАУЧНЫЕ ОБЗОРЫREVIEWЭпигенетическое репрограммирование ДНК в гаметах и доимплантационных эмбрионах человекаEpigenetic reprogramming in human gametes and preimplantation embryosТихоновА. В.TikhonovA. V.tixonov5790@gmail.comЕфимоваО. А.EfimovaO. A.noemail@neicon.ruПендинаА. А.PendinaA. A.noemail@neicon.ruБарановВ. С.BaranovV. S.noemail@neicon.ruНИИ акушерства, гинекологии и репродуктологии им. Д.О. Отта; Санкт-Петербургский государственный университет; Диагностический центр (медико-генетический)РоссияD.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology; St.Petersburg State UniversityRussian FederationНИИ акушерства, гинекологии и репродуктологии им. Д.О. Отта; Санкт-Петербургский государственный университетРоссияD.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology; St.Petersburg State UniversityRussian Federation2017190920171651725Copyright © Тихонов А.В., Ефимова О.А., Пендина А.А., Баранов В.С., 20172017Тихонов А.В., Ефимова О.А., Пендина А.А., Баранов В.С.Tikhonov A.V., Efimova O.A., Pendina A.A., Baranov V.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medgen-journal.ru/jour/article/view/263

В обзоре приведены новые данные об эпигенетическом репрограммировании генома в гаметогенезе и доимплантационном эмбриогенезе человека. Суммированы современные представления о динамических изменениях метилирования цитозина ДНК - ключевого механизма эпигенетической регуляции генома - в гаметах и у эмбрионов доимплантационных стадий развития. Рассмотрены различия в динамике и механизмах репрограммирования импринтированных и неимпринтированных участков ДНК в мужских и женских половых клетках.

In this review, we present recent data on the epigenetic reprogramming in human gametogenesis and preimplantation embryogenesis. We summarize current knowledge on the dynamic changes of DNA methylation - the key mechanism of genome epigenetic regulation - in gametes and preimplantation embryos. We also discuss the differences in dynamics and mechanisms of imprinted and non-imprinted regions reprogramming in male and female germ cells.

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The authors declare that there are no conflicts of interest present.