medgenМедицинская генетикаMedical Genetics2073-7998Publishing House «Genius Media» LLC10.25557/2073-7998.2025.03.50-68medgen-2626Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHПолиморфные варианты гена APOΕ (SNPs rs7412 и rs429358) в коренных популяциях Восточной и Южной СибириPolymorphism of the APOΕ gene, rs7412 C>T (Arg158Cys) and rs429358 T>C (Cys112Arg), in indigenous populations of Eastern and Southern SiberiaТийсР. П.TiisR. P.

630090, г. Новосибирск, пр. Ак. Лаврентьева, д. 10

10, Prospekt Lavrentyeva, Novosibirsk, 630090

kruosana@mail.ruТабихановаЛ. Э.TabikhanovaL. E.

630090, г. Новосибирск, пр. Ак. Лаврентьева, д. 10

10, Prospekt Lavrentyeva, Novosibirsk, 630090

ЛичманД. В.LichmanD. V.

630090, г. Новосибирск, пр. Ак. Лаврентьева, д. 10

10, Prospekt Lavrentyeva, Novosibirsk, 630090

ВоронинаЕ. Н.VoroninaE. N.

630090, г. Новосибирск, пр. Ак. Лаврентьева, 8

8, Prospekt Lavrentyeva, Novosibirsk, 630090

ОсиповаЛ. П.OsipovaL. P.

630090, г. Новосибирск, пр. Ак. Лаврентьева, д. 10

10, Prospekt Lavrentyeva, Novosibirsk, 630090

ФилипенкоМ. Л.FilipenkoM. L.

630090, г. Новосибирск, пр. Ак. Лаврентьева, 8

8, Prospekt Lavrentyeva, Novosibirsk, 630090

Федеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наукРоссияInstitute of Cytology and Genetics, Siberian Branch of Russian Academy of SciencesRussian FederationФГБУН Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наукРоссияInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of SciencesRussian Federation2025120520252435068Copyright © Тийс Р.П., Табиханова Л.Э., Личман Д.В., Воронина Е.Н., Осипова Л.П., Филипенко М.Л., 20252025Тийс Р.П., Табиханова Л.Э., Личман Д.В., Воронина Е.Н., Осипова Л.П., Филипенко М.Л.Tiis R.P., Tabikhanova L.E., Lichman D.V., Voronina E.N., Osipova L.P., Filipenko M.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medgen-journal.ru/jour/article/view/2626

Аполипопротеин Е участвует в метаболизме липидов и во многих других важных процессах в организме. Полиморфизм в гене APOΕ имеет огромное влияние на риск развития и тяжесть течения таких серьезных заболеваний, как болезнь Альцгеймера, гиперлипопротеинемия III типа, сердечно-сосудистые, онкологические и многие другие. Поэтому важность исследования этого полиморфизма в человеческих популяциях не вызывает сомнений. В данной работе представлены частоты встречаемости генотипов гена APOΕ и его полиморфных вариантов ε2, ε3, ε4 в 8 популяциях коренных народов, проживающих на территориях Восточной и Южной Сибири (якутов, бурятов, телеутов, долган, нганасан, русских). Проведены межпопуляционные сравнения между изученными нами и некоторыми мировыми популяциями.

Apolipoprotein E is involved in lipid metabolism and many other important processes in the body. Polymorphism in the APOΕ gene has a huge impact on the risk of developing and severity of such serious diseases as Alzheimer’s disease, type III hyperproteinemia, cardiovascular, oncological and many others. Therefore, the importance of studying this polymorphism in human populations is undoubted. This paper presents the frequency of occurrence of APOΕ genotypes and its polymorphic variants ε2, ε3, ε4 in 8 populations of indigenous peoples living in Eastern and Southern Siberia (Yakuts, Buryats, Teleuts, Dolgans, Nganasans, Russians). Inter-population comparisons have been made between the populations studied by us and some of the world’s populations.

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The authors declare that there are no conflicts of interest present.