medgenМедицинская генетикаMedical Genetics2073-7998Publishing House «Genius Media» LLCmedgen-258Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHОтсутствие ассоциации полиморфизма rs6339 гена нейротрофинового рецептора тирозинкиназы типа 1 с шизофренией в армянской популяцииLack of association of rs6339 polymorphism of the neurotrophic tyrosine kinase receptor 1 with schizophrenia in Armenian populationЗахарянР. В.ZakharyanR. V.zakharyanr@gmail.comТелумянЕ. Г.TelumyanE. H.noemail@neicon.ruГеворкянА. П.GevorgyanA. P.noemail@neicon.ruАракелянА. А.ArakelyanA. A.noemail@neicon.ruИнститут молекулярной биологии Национальной академии наук Республики АрменияРоссияInstitute of Molecular Biology of the National Academy of Sciences of the Republic of ArmeniaRussian FederationЦентр медицинской диагностики «Альфа-бетта»РоссияDiagnosic medical center «Alfa betta»Russian Federation2017190920171644043Copyright © Захарян Р.В., Телумян Е.Г., Геворкян А.П., Аракелян А.А., 20172017Захарян Р.В., Телумян Е.Г., Геворкян А.П., Аракелян А.А.Zakharyan R.V., Telumyan E.H., Gevorgyan A.P., Arakelyan A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medgen-journal.ru/jour/article/view/258

Шизофрения - многофакторное полигенное расстройство, характеризующееся как генетической компонентой, так и воздействием факторов окружающей среды. Информация относительно ключевых генетических вариантов ассоциированных с данной патологией год из года пополняется новыми данными. В настоящей работе мы исследовали возможную ассоциацию шизофрении с однонуклеотидным полиморфизмом rs6339 гена NTRK1 , кодирующего нейротрофиновый рецептор тирозинкиназы типа 1. С этой целью образцы ДНК, выделенные из крови больных шизофренией и здоровых лиц, были генотипированы методом полимеразной цепной реакции с аллельспецифичными праймерами. Результаты проведенного исследования показали отсутствие ассоциации между риском развития шизофрении и исследованным однонуклеотидным полиморфизмом, что, однако, не исключает вовлечение других генетических вариаций этого гена или близлежащих полиморфизмов в патогенез шизофрении.

Schizophrenia is a multifactorial polygenic disease characterized by both genetic and environmental components. There is growing information about the genetic variations contributing to schizophrenia. In the current study we aimed to explore the potential association of single nucleotide polymorphism rs6339 of the NTRK1 gene with schizophrenia. For this purpose, DNA samples isolated from the blood of patients with schizophrenia and healthy individuals were genotypes using polymerase chain reaction with allele-specific primers. The obtained results demonstrated no association between schizophrenia development risk and the studied genetic variant. However, the absence of association found in this study does not exclude the association of other genetic polymorphisms of this gene or nearby locus with schizophrenia.

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The authors declare that there are no conflicts of interest present.