medgenМедицинская генетикаMedical Genetics2073-7998Publishing House «Genius Media» LLC10.25557/2073-7998.2024.05.22-30medgen-2475Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHАссоциация полиморфизма rs1800795 гена IL 6 с восприимчивостью и тяжестью COVID-19: метаанализAssociation of IL 6 rs1800795 genetic variation with the susceptibility and severity of COVID-19: A meta-analysisИвановаЕ. С.IvanovaE. S.

344006, г. Ростов-на-Дону, ул. Большая Садовая, д. 105/42

105/42, Bolshaya Sadovaya st., Rostov-on-Don, 344006

ИдМ. А.EidM. A.

344006, г. Ростов-на-Дону, ул. Большая Садовая, д. 105/42

105/42, Bolshaya Sadovaya st., Rostov-on-Don, 344006

ШкуратТ. П.ShkuratT. P.

344006, г. Ростов-на-Дону, ул. Большая Садовая, д. 105/42

105/42, Bolshaya Sadovaya st., Rostov-on-Don, 344006

Южный федеральный университетРоссияSouthern Federal UniversityRussian Federation2024030820242352230Copyright © Иванова Е.С., Ид М.А., Шкурат Т.П., 20242024Иванова Е.С., Ид М.А., Шкурат Т.П.Ivanova E.S., Eid M.A., Shkurat T.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medgen-journal.ru/jour/article/view/2475

Коронавирусная инфекция 2019 года (COVID-19) является высококонтагиозным инфекционным заболеванием, вызвавшим глобальную пандемию. Различия в симптомах у пациентов с COVID-19 сделали важным поиск факторов, которые могут играть значительную роль в ее патогенезе. Целью настоящего исследования было изучение связи генетической вариации интерлейкина 6 (IL-6) rs1800795 как с восприимчивостью, так и с тяжестью заболевания COVID-19 путем проведения метаанализа имеющихся в литературе данных. Был проведен поиск по нескольким базам данных с использованием определенных ключевых слов, и в общей сложности в анализ были включены 12 полнотекстовых статей. Не было обнаружено никакой связи rs1800795 в гене IL 6 с восприимчивостью к COVID-19. Однако была обнаружена значимая связь между изучаемым полиморфизмом и тяжестью COVID-19 при рецессивной модели наследования (OR =2,11, 95% CI [1,12; 3,98], р=0,02). Насколько нам известно, этот мета-анализ является первым, в котором изучается связь IL6 rs1800795 как с восприимчивостью, так и с тяжестью заболевания. 

Coronavirus disease 2019 (COVID-19) is a highly contagious infectious disease, which caused a global pandemic. The differences of symptoms among COVID-19 patients made it important to search for the factors that may play a significant role in its pathogenesis. The aim of the current study was to investigate the association of interleukin 6 (IL-6) genetic variation rs1800795 with both susceptibility and severity of COVID-19, by performing a meta-analysis of the available data in the literature. Several databases were searched using specific keywords, and a total of 12 full-text articles were included in the analysis. No association was found with the COVID-19 susceptibility. However, a significant association was found between the studied polymorphism and the COVID-19 severity in the recessive model of inheritance (OR =2.11, 95% CI [1.12, 3.98], p=0.02). To our knowledge, this meta-analysis is the first to study the association of IL6 rs1800795 with both susceptibility and severity of COVID-19, and its results reflect the current published data, and may serve as a guide for further research. 

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The authors declare that there are no conflicts of interest present.