medgenМедицинская генетикаMedical Genetics2073-7998Publishing House «Genius Media» LLC10.25557/2073-7998.2024.04.16-24medgen-2459Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHПолиморфизм гена NOS1 и риск развития послеродового атонического кровотечения у женщин узбекской этнической группыNOS1 gene polymorphism and risk of postpartum hemorrhage in Uzbek womenАшуроваУ. А.AshurovaU. A.

100109, г. Ташкент, ул. Фаробий, д. 2

2, Forobiy st., Tashkent, 100109

umida.ashurova@gmail.comНажмутдиноваД. К.NajmutdinovaD. K.

100109, г. Ташкент, ул. Фаробий, д. 2

2, Forobiy st., Tashkent, 100109

БобоевК. Т.BoboevK. T.

100115, г. Ташкент, Чиланзарский р-н, ул. Арнасай, д. 16/ 1А

16/1А, Arnasay st., Chilanzar district, Tashkent, 100115

Ташкентская медицинская академияУзбекистанTashkent Medical AcademyUzbekistanРеспубликанский специализированный научно-практический медицинский центр гематологииУзбекистанRepublican Specialized Scientific Practical Medical Center of HematologyUzbekistan2024130720242341624Copyright © Ашурова У.А., Нажмутдинова Д.К., Бобоев К.Т., 20242024Ашурова У.А., Нажмутдинова Д.К., Бобоев К.Т.Ashurova U.A., Najmutdinova D.K., Boboev K.T.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medgen-journal.ru/jour/article/view/2459

Введение. Учитывая рост распространенности послеродовых кровотечений, на сегодня проведено немало работ, посвященных патогенезу атонии матки. Тем не менее, изучение и поиск генов-кандидатов, участвующих в процессах развития атонии матки, остаются актуальными.Цель: оценить связь генетического полиморфизма NOS1 (rs41279104) с дисфункцией миометрия и риском развития атонического послеродового кровотечения у женщин узбекской этнической группы.Методы. Нами обследована 101 женщина с послеродовым атоническим кровотечением различной степени тяжести. Всем женщинам были проведены клинико-лабораторные и инструментальные исследования, включающие стандартные методики сбора анамнеза и физикального обследования. Для молекулярно-генетической детекции полиморфизма rs41279104 в гене NOS1 были использованы образцы геномной ДНК.Результаты. При носительстве аллеля А риск развития послеродовой атонии матки у роженицы со сроком гестации 37-42 недели увеличивается в 1,7 раз (χ2 =4,2, OR=1,7, р=0,05). Однако эти выводы основаны на ограниченном объеме данных, и для подтверждения установленной ассоциации необходимо проведение дополнительных исследований с использованием более крупных выборок.

Background. Given the increasing prevalence of postpartum hemorrhage, a lot of work has been done today on the pathogenesis of uterine atony. Nevertheless, the study and search for candidate genes involved in the development of uterine atony remain relevant.Objective: to evaluate association of the genetic polymorphism NOS1 rs41279104 with myometrial dysfunction and the risk of postpartum uterine atony in Uzbek women.Methods. We examined 101 women who developed postpartum atonic bleeding of varying severity. Common laboratory and instrumental examinations were performed on all women. Genomic DNA was used for the detection of the NOS1 rs41279104.Results. Allele A is the risk factor for postpartum uterine atony more than 1.7 times (χ2 = 4.2, OR = 1.7, p = 0.05) in parturient women with a gestational age of 37-42 weeks. Conclusion. The results of our research indicate that the NOS1 rs41279104 has an association with postpartum atonic bleeding. In women with 37-42 weeks of gestation, allelic variant A may be a risk factor for PPH.

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The authors declare that there are no conflicts of interest present.