medgenМедицинская генетикаMedical Genetics2073-7998Publishing House «Genius Media» LLC10.25557/2073-7998.2024.02.27-33medgen-2419Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHРоль гена ACE в развитии тяжелой формы COVID-19 у беременных женщинThe role of the ACE gene in the development of severe form of COVID-19 in pregnant womenКомиловаМ. О.KomilovaM. O.

г. Андижан,  ул. Юсуфа Атабекова, д. 1

Andijan

mehriniz.komilova@bk.ruБобоевК. Т.BoboevK. T.

г. Ташкент, ул. Арнасай, д. 16/1А

Tashkent

ЗуфароваШ. А.ZufarovaSh. A.

г. Ташкент, ул. Мирзо Улугбека, д. 132А

Tashkent

ЮлдашеваА. С.YuldashevaA. S.

г. Андижан, ул. Юсуфа Атабекова, д. 1

Andijan

Андижанский государственный медицинский институтУзбекистанAndijan State Medical InstituteUzbekistanРеспубликанский специализированный научно-практический медицинский центр гематологииУзбекистанRepublican Specialized Scientific and Practical Medical Center of HematologyUzbekistanРеспубликанский центр репродуктивного здоровья населенияУзбекистанRepublican Population Reproductive Health CenterUzbekistan2024250320242322733Copyright © Комилова М.О., Бобоев К.Т., Зуфарова Ш.А., Юлдашева А.С., 20242024Комилова М.О., Бобоев К.Т., Зуфарова Ш.А., Юлдашева А.С.Komilova M.O., Boboev K.T., Zufarova S.A., Yuldasheva A.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medgen-journal.ru/jour/article/view/2419

Использование генетических полиморфизмов при определении патогенеза заболевания повышает эффективность ранней диагностики и профилактики тяжелой формы коронавирусной инфекции. COVID-19 и его осложнения пневмонией являются потенциальным фактором риска для беременных и могут иметь негативные последствия как для матери, так и для плода. В настоящее время особое внимание уделяется изучению роли генетических факторов в возникновении вспышки коронавируса. Цель исследования: определить роль полиморфизма I/D Alu-элемента гена  ACE  в патогенезе COVID-19. По результатам молекулярно-генетического обследования и статистического анализа частоты аллелей и генотипов полиморфизма I/D гена ACE  у беременных, инфицированных коронавирусом, не имели достоверных отличий от таковых в контрольной группе (р=0,05) и, таким образом, этот полиморфизм не ассоциирован с развитием COVID-19 и его осложнений.

The use of genetic polymorphisms in determining the pathogenesis of the disease increases the effectiveness of early diagnosis and preventive measures of severe form of coronavirus. COVID-19 and its complications with pneumonia are a potential risk factor for pregnant women and can have negative consequences for both the mother and the fetus. Currently, special attention is paid to the study of the role of genetic factors in the outbreak of the coronavirus. The aim of the study: to determine the role of the ACE  gene Alu-element I/D polymorphism in the pathogenesis of COVID-19. According to the results of molecular-genetic examination and statistical analysis, alleles and genotypes of ACE  gene I/D polymorphism in pregnant women infected with coronavirus did not have significant differences compared to the control group (p=0.05). Conclusion: It is impossible to use this locus of the  ACE  gene to predict COVID-19 and its complications.

генотипген ACEаллелибиомаркерысиндром высвобождения цитокиновхемокинОРДСотношение шансовGenotypeACE geneallelesbiomarkerscytokine release syndromechemokineARDSodds ratioReferencesHubert C., Houot A.M., Corvol P., Soubrier F. Structure of the angiotensin I-converting enzyme gene. Two alternate promoters correspond to evolutionary steps of a duplicated gene. J Biol Chem. 1991;266(23):15377-15383.Hubert C., Houot A.M., Corvol P., Soubrier F. Structure of the angiotensin I-converting enzyme gene. Two alternate promoters correspond to evolutionary steps of a duplicated gene. J Biol Chem. 1991;266(23):15377-15383.Zhong W.G., Wang Y., Zhu H., Zhao X. Meta-Analysis of Angiotensin-Converting Enzyme I/D Polymorphism as a Risk Factor for Preeclampsia in Chinese Women. Genet. Mol. Res. 2012;11:2268–2276.Zhong W.G., Wang Y., Zhu H., Zhao X. Meta-Analysis of Angiotensin-Converting Enzyme I/D Polymorphism as a Risk Factor for Preeclampsia in Chinese Women. Genet. Mol. Res. 2012;11:2268–2276.Rigat B., Hubert C., Alhenc-Gelas F., Cambien F., Corvol P., Soubrier F. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest. 1990;86(4):1343-1346.Rigat B., Hubert C., Alhenc-Gelas F., Cambien F., Corvol P., Soubrier F. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest. 1990;86(4):1343-1346.Wang K., Li Y., Dai C., et al. Characterization of the relationship between APOBEC3B deletion and ACE Alu insertion. PLoS One. 2013;8(5):e64809.Wang K., Li Y., Dai C., et al. Characterization of the relationship between APOBEC3B deletion and ACE Alu insertion. PLoS One. 2013;8(5):e64809.Navarrete H.P., Soler L.H., Mares R.E., Ramos M.A. Frequency of Alu insertions within the ACE and PR loci in Northwestern Mexicans. BMC Res Notes. 2017;10(1):339.Navarrete H.P., Soler L.H., Mares R.E., Ramos M.A. Frequency of Alu insertions within the ACE and PR loci in Northwestern Mexicans. BMC Res Notes. 2017;10(1):339.Gupta A., Madhavan M.V., et al. Extrapulmonary manifestations of COVID-19. Nat Med. 2020;26:1017–1032.Gupta A., Madhavan M.V., et al. Extrapulmonary manifestations of COVID-19. Nat Med. 2020;26:1017–1032.Mafra F.F.P., Gattai P.P., Macedo M.M., Mori M.A., Araujo R.C. The angiotensin-I-converting enzyme insertion/deletion in polymorphic element codes for an AluYa5 RNA that downregulates gene expression. Pharmacogenomics J. 2018;18(4):517-527.Mafra F.F.P., Gattai P.P., Macedo M.M., Mori M.A., Araujo R.C. The angiotensin-I-converting enzyme insertion/deletion in polymorphic element codes for an AluYa5 RNA that downregulates gene expression. Pharmacogenomics J. 2018;18(4):517-527.Mariner P.D., Walters R.D., Espinoza C.A., et al. Human Alu RNA is a modular transacting repressor of mRNA transcription during heat shock. Mol Cell. 2008;29(4):499-509.Mariner P.D., Walters R.D., Espinoza C.A., et al. Human Alu RNA is a modular transacting repressor of mRNA transcription during heat shock. Mol Cell. 2008;29(4):499-509.Delanghe J.R., Speeckaert M.M., De Buyzere M.L. The host’s angiotensin-converting enzyme polymorphism may explain epidemiological findings in COVID-19 infections. ClinChimActa. 2020;505:192-193.Delanghe J.R., Speeckaert M.M., De Buyzere M.L. The host’s angiotensin-converting enzyme polymorphism may explain epidemiological findings in COVID-19 infections. ClinChimActa. 2020;505:192-193.Onishi M., Morimoto S., Yang J., Okaishi K., Katsuya T., Shimizu M. et al. Association of angiotensin-I converting enzyme DD genotype with influenza pneumonia in the elderly. Geriatr Gerontol Int. 2002;2(1):8–15.Onishi M., Morimoto S., Yang J., Okaishi K., Katsuya T., Shimizu M. et al. Association of angiotensin-I converting enzyme DD genotype with influenza pneumonia in the elderly. Geriatr Gerontol Int. 2002;2(1):8–15.Marshall R.P., Webb S., Bellingan G.J., et al. Angiotensin converting enzyme insertion/deletion polymorphism is associated with susceptibility and outcome in acute respiratory distress syndrome. Am J Respir Crit Care Med. 2002;166(5):646-650.Marshall R.P., Webb S., Bellingan G.J., et al. Angiotensin converting enzyme insertion/deletion polymorphism is associated with susceptibility and outcome in acute respiratory distress syndrome. Am J Respir Crit Care Med. 2002;166(5):646-650.Watkins W.S., Rogers A.R., Ostler C.T., et al. Genetic variation among world populations: inferences from 100 Alu insertion polymorphisms. Genome Res. 2003;13(7):1607-1618.Watkins W.S., Rogers A.R., Ostler C.T., et al. Genetic variation among world populations: inferences from 100 Alu insertion polymorphisms. Genome Res. 2003;13(7):1607-1618.Deng X., Zhang S., Jin K., Li L., Gu W., Liu M., et al. Angiotensin-converting enzyme I/D polymorphism and acute respiratory distress syndrome. J. Renin. Angiotensin. Aldosterone. Syst. 2015;16(4): 780–786.Deng X., Zhang S., Jin K., Li L., Gu W., Liu M., et al. Angiotensin-converting enzyme I/D polymorphism and acute respiratory distress syndrome. J. Renin. Angiotensin. Aldosterone. Syst. 2015;16(4): 780–786.Cenanovic M., Dogan S., Asic A., Besic L., Marjanovic D. Distribution of the ACE1 D Allele in the Bosnian-Herzegovinian Population and its Possible Role in the Regional Epidemiological Picture of COVID-19. Genet Test Mol Biomarkers. 2021;25(1):55-58.Cenanovic M., Dogan S., Asic A., Besic L., Marjanovic D. Distribution of the ACE1 D Allele in the Bosnian-Herzegovinian Population and its Possible Role in the Regional Epidemiological Picture of COVID-19. Genet Test Mol Biomarkers. 2021;25(1):55-58.Karakaş Çelik S., Çakmak Genç G., Pişkin N., et al. Polymorphisms of ACE (I/D) and ACE2 receptor gene (Rs2106809, Rs2285666) are not related to the clinical course of COVID-19: A case study. J Med Virol. 2021;93(10):5947-5952.Karakaş Çelik S., Çakmak Genç G., Pişkin N., et al. Polymorphisms of ACE (I/D) and ACE2 receptor gene (Rs2106809, Rs2285666) are not related to the clinical course of COVID-19: A case study. J Med Virol. 2021;93(10):5947-5952.Chan K.C., Tang N.L., Hui D.S., et al. Absence of association between angiotensin converting enzyme polymorphism and development of adult respiratory distress syndrome in patients with severe acute respiratory syndrome: a case control study. BMC Infect Dis. 2005;5:26Chan K.C., Tang N.L., Hui D.S., et al. Absence of association between angiotensin converting enzyme polymorphism and development of adult respiratory distress syndrome in patients with severe acute respiratory syndrome: a case control study. BMC Infect Dis. 2005;5:26Yamamoto N., Nishida N., Yamamoto R., et al. Angiotensin-Converting Enzyme (ACE) 1 Gene Polymorphism and Phenotypic Expression of COVID-19 Symptoms. Genes (Basel). 2021;12(10):1572.Yamamoto N., Nishida N., Yamamoto R., et al. Angiotensin-Converting Enzyme (ACE) 1 Gene Polymorphism and Phenotypic Expression of COVID-19 Symptoms. Genes (Basel). 2021;12(10):1572.Verma S., Abbas M., Verma S., et al. Impact of I/D polymorphism of angiotensin-converting enzyme 1 (ACE1) gene on the severity of COVID-19 patients. Infect Genet Evol. 2021;91:104801.Verma S., Abbas M., Verma S., et al. Impact of I/D polymorphism of angiotensin-converting enzyme 1 (ACE1) gene on the severity of COVID-19 patients. Infect Genet Evol. 2021;91:104801.Aziz M.A., Islam M.S. Association of ACE1 I/D rs1799752 and ACE2 rs2285666 polymorphisms with the infection and severity of COVID-19: A meta-analysis. Mol Genet Genomic Med. 2022;10(11):e2063.Aziz M.A., Islam M.S. Association of ACE1 I/D rs1799752 and ACE2 rs2285666 polymorphisms with the infection and severity of COVID-19: A meta-analysis. Mol Genet Genomic Med. 2022;10(11):e2063.Gunal O., Sezer O., Ustun G.U., et al. Angiotensin-converting enzyme-1 gene insertion/deletion polymorphism may be associated with COVID-19 clinical severity: a prospective cohort study. Ann Saudi Med. 2021;41(3):141-146.Gunal O., Sezer O., Ustun G.U., et al. Angiotensin-converting enzyme-1 gene insertion/deletion polymorphism may be associated with COVID-19 clinical severity: a prospective cohort study. Ann Saudi Med. 2021;41(3):141-146.Rezaei M., Mohammadpour H., Eftekhari M., et al. The role of angiotensin I converting enzyme insertion/deletion polymorphism in the severity and outcomes of COVID-19 patients. Front Genet. 2022;13:1035796.Rezaei M., Mohammadpour H., Eftekhari M., et al. The role of angiotensin I converting enzyme insertion/deletion polymorphism in the severity and outcomes of COVID-19 patients. Front Genet. 2022;13:1035796.Pabalan N., Tharabenjasin P., Suntornsaratoon P., Jarjanazi H., Muanprasat C. Ethnic and age-specific acute lung injury/acute respiratory distress syndrome risk associated with angiotensin-converting enzyme insertion/deletion polymorphisms, implications for COVID-19: A meta-analysis. Infect Genet Evol. 2021;88:104682.Pabalan N., Tharabenjasin P., Suntornsaratoon P., Jarjanazi H., Muanprasat C. Ethnic and age-specific acute lung injury/acute respiratory distress syndrome risk associated with angiotensin-converting enzyme insertion/deletion polymorphisms, implications for COVID-19: A meta-analysis. Infect Genet Evol. 2021;88:104682.

The authors declare that there are no conflicts of interest present.