medgenМедицинская генетикаMedical Genetics2073-7998Publishing House «Genius Media» LLCmedgen-225Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHАнализ генов цитокиновой сети в развитии «обратной» коморбидности для бронхиальной астмы и туберкулезаAnalysis of cytokine network`s genes in the development of «inverse» comorbidity between asthma and tuberculosisБрагинаЕ. Ю.BraginaE. Yu.elena.bragina@medgenetics.ruФрейдинМ. Б.FreidinM. B.noemail@neicon.ruБабушкинаН. П.BabushkinaN. P.noemail@neicon.ruГараеваА. Ф.GaraevaA. F.noemail@neicon.ruКолоколоваО. В.KolokolovaO. V.noemail@neicon.ruЖалсановаИ. Ж.ZhalsanovaI. Z.noemail@neicon.ruПузыревВ. П.PuzyrevV. P.noemail@neicon.ruТомский национальный исследовательский медицинский центр Российской академии наукРоссияResearch Institute of Medical GeneticsRussian FederationСибирский государственный медицинский университетРоссияSiberian State Medical UniversityRussian FederationТомский национальный исследовательский медицинский центр Российской академии наук; Сибирский государственный медицинский университетРоссияResearch Institute of Medical Genetics; Siberian State Medical UniversityRussian Federation2017180420171612024Copyright © Брагина Е.Ю., Фрейдин М.Б., Бабушкина Н.П., Гараева А.Ф., Колоколова О.В., Жалсанова И.Ж., Пузырев В.П., 20172017Брагина Е.Ю., Фрейдин М.Б., Бабушкина Н.П., Гараева А.Ф., Колоколова О.В., Жалсанова И.Ж., Пузырев В.П.Bragina E.Y., Freidin M.B., Babushkina N.P., Garaeva A.F., Kolokolova O.V., Zhalsanova I.Z., Puzyrev V.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medgen-journal.ru/jour/article/view/225

В контексте исследования генетических причин исключительно редкой сочетаемости атопической бронхиальной астмы (БА) и туберкулеза (ТБ) проведен ассоциативный анализ полиморфизма генов IL1B, IL8, IL10, TNF, TNFRSF1B, CXCL10 у 713 индивидов, проживающих на территории г. Томска и Томской области. Выявлена ассоциация полиморфизма гена CXCL10 rs56061981 с развитием ТБ. Установлена ассоциация полиморфного варианта IL10 rs1800872 с развитием, как БА, так и ТБ легких. Таким образом, полученные данные свидетельствуют в пользу значимости гена IL10 в развитии БА и ТБ, которые требуют дальнейших исследований сигнального пути IL10 для уточнения возможной роли в развитии «обратной» коморбидности между инфекционными и аллергическими болезнями.

In the context of studying a genetic causes of extremely rare coexistence of atopic bronchial asthma (BA) and tuberculosis (TB) we’ve held an associative analysis of polymorphism IL1B, IL8, IL10, TNF, TNFRSF1B, CXCL10 genes in 713 individuals living on the Tomsk and Tomsk region. The relation of rs56061981* CXCL10 in the development of TB was established. Furthermore, association of variant rs1800872 of IL10 with the development of BA and pulmonary TB either was ascertained. Thus, obtained data support the importance of IL10 gene in BA and TB development that require further research IL10 signaling pathway to clarify the possible role in pathogenesis of the «inverse» comorbidity between infectious and allergic diseases.

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The authors declare that there are no conflicts of interest present.