medgenМедицинская генетикаMedical Genetics2073-7998Publishing House «Genius Media» LLC10.1234/XXXX-XXXX-2015-1-13-19medgen-2Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHЭФФЕКТИВНОСТЬ МЕДИКО-ГЕНЕТИЧЕСКОГО ПРОГНОЗИРОВАНИЯ РИСКА ХРОМОСОМНОЙ ПАТОЛОГИИ ПЛОДА ПОСЛЕ ЭКОEFFICIENCY OF FETAL CHROMOSOMAL ABNORMALITIES RISK PREDICTION IN IVF PREGNANCIESЛатыповА. Ш.LatypovA. Sh.

123995, Москва, ул. Баррикадная, д.2/1, стр. 1

Barrikadnaya str., 2/1-1, Moscow, 123995, Russia

artlat@mail.ruГБОУ ДПО «российская медицинская академия последипломного образования» Министерства здравоохранения РФ,РоссияRussian Medical Academy of Postgraduate Education StudiesRussian Federation2015201220151411319Copyright © Латыпов А.Ш., 20152015Латыпов А.Ш.Latypov A.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medgen-journal.ru/jour/article/view/2

We analyzed the results of prenatal screening in women achieved pregnancy through IVF. There were examined 366 pregnant women: 93 twins (one of them monochorionic), 1 triplet and 262 singleton pregnancies. Integrated risk assessment was based on ultrasound and biochemical markers and 1% of threshold the high risk group consisted of 12 fetuses (2.5%). Invasive diagnostic procedure was performed in 7 pregnancies, 4 cases with chromosomal abnormalities were found, including 3 case of trisomy 21, and 1 case of trisomy 18. The total frequency of chromosomal abnormalities was 1 of 91 (1,08%) cases, andtrisomy21 —1 of 114cases. The integrated risk assessment of chromosomal abnormalities in IVF pregnancies has high efficacy and sensitivity. The median value definition for the biochemical indicators and a taking into account population and reproductive technology-related peculiarity are desirable to decrease the number of false-positive results.

 

 

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The authors declare that there are no conflicts of interest present.