medgenМедицинская генетикаMedical Genetics2073-7998Publishing House «Genius Media» LLCmedgen-186Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHГены семейства нейрексинов (CNTNAP2 и NRXN1): их роль в развитии математической тревожностиNeurexin family genes (CNTNAP2 and NRXN1): their involvement in mathematics anxietyКазанцеваА. В.KazantsevaA. V.Kazantsa@mail.ruЕникееваР. Ф.EnikeevaR. F.noemail@neicon.ruРомановаА. Р.RomanovaA. R.noemail@neicon.ruБашкатовС. А.BashkatovS. A.noemail@neicon.ruГаляутдиноваС. И.GalyautdinovaS. I.noemail@neicon.ruТихомироваТ. Н.TikhomirovaT. T.noemail@neicon.ruМалыхС. Б.MalykhS. B.noemail@neicon.ruХуснутдиноваЭ. К.KhusnutdinovaE. K.noemail@neicon.ruИнститут биохимии и генетики Уфимского научного центра РАНРоссияUfa Scientific Center of Russian Academy of SciencesRussian FederationБашкирский государственный университетРоссияBashkir State UniversityRussian FederationСтерлитамакский филиал Федерального государственного бюджетного образовательного учреждения высшего профессионального образования «Башкирский государственный университет»РоссияSterlitamak, RussiaRussian Federation«Психологический институт Российской Академии ОбразованияРоссияPsychological Institute of Russian Academy of EducationRussian FederationИнститут биохимии и генетики Уфимского научного центра РАН; Башкирский государственный университетРоссияUfa Scientific Center of Russian Academy of Sciences; Bashkir State UniversityRussian Federation20162601201715111723Copyright © Казанцева А.В., Еникеева Р.Ф., Романова А.Р., Башкатов С.А., Галяутдинова С.И., Тихомирова Т.Н., Малых С.Б., Хуснутдинова Э.К., 20172017Казанцева А.В., Еникеева Р.Ф., Романова А.Р., Башкатов С.А., Галяутдинова С.И., Тихомирова Т.Н., Малых С.Б., Хуснутдинова Э.К.Kazantseva A.V., Enikeeva R.F., Romanova A.R., Bashkatov S.A., Galyautdinova S.I., Tikhomirova T.T., Malykh S.B., Khusnutdinova E.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medgen-journal.ru/jour/article/view/186

Математика с каждым годом приобретает все большее значение в современном обществе. Она широко используется в физике, астрономии, биологии, инженерном деле, организации производства и многих других областях теоретической и прикладной деятельности. Однако многие люди намеренно избегают выбора специальностей, связанных с математикой. Это отчасти может быть объяснено математической тревожностью (МТ), выражающейся в чувстве сильного беспокойства и неловкости, связанном со сложностями в манипулировании числами как в академических, так и в бытовых ситуациях. Белки, кодируемые генами нейрексина 1 ( NRXN1 ) и контактин-ассоциированного белка ( CNTNAP2 ), вовлечены в регуляцию синаптической пластичности, являющейся одним из механизмов формирования рабочей памяти, а значит, способности справиться со стрессовой ситуацией. Целью данной работы являлась оценка вовлеченности полиморфных вариантов генов NRXN1 (rs4971648, rs1045881) и CNTNAP2 (rs2710102, rs2530310) в развитие МТ. В исследовании приняли участие 523 здоровых индивида из Республики Башкортостан (средний возраст 20,3 ± 3,87 года), прошедшие оценку МТ с использованием опросника MARS-E. Генотипирование проводили методом ПЦР-ПДРФ. Статистический анализ был осуществлен с использованием программы Plink v.1.07. Анализ ген-средовых взаимодействий позволил установить, что индивиды, родившиеся не вторыми в семье (b = -6,77; Р = 0,021) и/или воспитанные в семье менее чем с тремя детьми (b = -10,37; Р = 0,012) при наличии у них аллеля rs2530310*А в гене CNTNAP2 демонстрировали повышение МТ. Полученные данные указывают на модифицирующий эффект таких средовых факторов, как «порядок рождения» индивида и «число детей в семье» на ассоциации гена CNTNAP2 с различиями в уровне МТ.

Mathematics is acquiring ever greater significance in the modern society. Mathematics represents an everyday tool in physics, astronomy, biology, engineering, management and other fields of theoretical and applied activities. However, many people deliberately avoid choosing courses including mathematics operations. This observation might partly be explained by an increased mathematical anxiety (MA) manifested as a sense of high anxiety and awkwardness connected with difficulties in manipulations with numbers in both academic and everyday situations. The proteins encoded by contactin associated protein-like 2(CNTNAP2)and neurexin-1 genes (NRXN1) are involved in the regulation of synaptic plasticity representing one of the mechanisms of working memory and, hence, in resistance to stressful life events. The present study aimed to examine the role of NRXN1 (rs4971648, rs1045881) and CNTNAP2 (rs2710102, rs2530310) gene polymorphisms in math anxiety. The study involved 523 healthy individuals from Republic of Bashkortostan (75% women) (mean age 20.3 ± 3.87 years). MA level was assessed via Mathematics Anxiety Rating Scale- Elementary Form (MARS-E). SNPs genotyping was performed via PCR-RFLP. Statistical analysis was conducted with Plink v.1.07. According to the analysis of gene-environment interactions, individuals with the highest or lowest order of birth (b = -6.77; p = 0.021) and/or with less than one sibling (b = -10.37; P = 0.012) demonstrated an increased MA in the presence ofCNTNAP2 rs2530310 A-allele. Revealed findings evidence in modulating effect of environmental factors (i.e. «birth order» and «number of siblings in the family») in association of CNTNAP2 gene with individual variations in MA.

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The authors declare that there are no conflicts of interest present.