medgenМедицинская генетикаMedical Genetics2073-7998Publishing House «Genius Media» LLC10.25557/2073-7998.2021.01.3-11medgen-1837Research ArticleНАУЧНЫЕ ОБЗОРЫREVIEWСемейная средиземноморская лихорадка, женская и мужская фертильность: литературный обзорFamilial Mediterranean Fever (FMF), Female and Male Fertility: Literature ReviewСоцкийП. О.SotskiyP. O.pavel.sotskiy@gmail.comЦентр медицинской гeнетики и первичной охраны здоровьяРоссияCenter of Medical Genetics and Primary Health CareRussian Federation202111032021201311Copyright © Соцкий П.О., 20212021Соцкий П.О.Sotskiy P.O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medgen-journal.ru/jour/article/view/1837

Семейная средиземноморская лихорадка (CCЛ) - моногенное наследственное аутовоспалительное заболевание, характеризующееся периодически повторяющимися приступами лихорадки, серозитами разной локализации, артритами, эризипелоидоподобным высыпанием. Хотя ССЛ болеют преимущественно представители популяций восточно-средиземноморского происхождения (турки, армяне, арабы, евреи-сефарды), в наши дни болезнь регистрируется по всему миру, что связано с непрерывными миграционными процессами. Потенциальные осложнения ССЛ (фиброз и амилоидоз) и их лечение колхицином могут повлиять на репродуктивную систему больных либо путем обструкции маточных труб, либо через избыточное образование дефектных сперматозоидов и ооцитов, либо вследствие овариальной/тестикулярной недостаточности. Амилоидоз с преимущественным отложением амилоида в яичниках и яичках может приводить к женскому и мужскому бесплодию. У мужчин колхицин в редких случаях индуцирует олиго/азооспермию. У женщин основными причинами бесплодия в прошлом считались дисовуляция и перитонеальная адгезия. В последние годы ситуация с фертильностью значительно улучшилась благодаря применению колхицина. В обзоре обобщается текущая информация о взаимосвязи женской и мужской фертильности с ССЛ и приемом колхицина; излагаются современные подходы к восстановлению репродуктивной функции при бесплодии. Акцент сделан на аспектах безопасности терапии, основные положения которой представлены в клинических рекомендациях по лечению ССЛ Европейской антиревматической лиги (EULAR,2016).

Familial Mediterranean fever (FMF) is a monogenic inherited autoinflammatory disease characterized by recurrent episodes (attacks) of fever, serositis of different localization, arthritis, erysipelaslike rashes. Eastern Mediterranean persons (especially Turks, Armenians, Arabs, Sephardic Jews) are most frequently affected. Nowadays the disease is registered throughout the world because of migration processes. Potential complications of FMF (fibrosis and amyloidosis) and their treatment with colchicine may affect the reproductive system either by salpinx obstruction causing mechanical infertility, or by excessive formation of defective sperm and oocytes, either due to ovarian /testicular insufficiency. Amyloidosis can lead to female and male infertility with amyloid preponderance in the ovaries and testicles. Colchicine rarely induces oligo/ azoospermia in men. In women, disovulation and peritoneal adhesion were the main causes of infertility in the past. In recent years, the fertility situation has improved considerably due to the use of colchicine. The review summarizes current information on the relationship between female and male fertility with FMF and colchicine; modern approaches to restoring reproductive function in infertility are outlined. The focus is on the aspects of the safety of therapy, the main provisions of which are presented in the clinical recommendations for treatment of the FMF of the European Anti-Rheumatic League (EULAR, 2016).

семейная средиземноморская лихорадкаженское и мужское бесплодиеколхицинолиго-азооспермияэкстракорпоральное оплодотворение (ЭКО)Familial Mediterranean Feverfemale and male infertilitycolchicineoligo/azoospermiain vitro fertilization (IVF)ReferencesSiegal S. Benign paroxysmal peritonitis. Ann Intern Med. 1945;23(1):1Siegal S. Benign paroxysmal peritonitis. Ann Intern Med. 1945;23(1):1Ben-Chetrit E., Touitou I. Familial mediterranean Fever in the world. Arthritis Rheum. 2009;61(10):1447-1453.Ben-Chetrit E., Touitou I. Familial mediterranean Fever in the world. Arthritis Rheum. 2009;61(10):1447-1453.Ben-Chetrit E., Levy M. Familial Mediterranean fever. Lancet 1998; 351:659-664. doi:10.1016/S0140-6736(97)09408-7Ben-Chetrit E., Levy M. Familial Mediterranean fever. Lancet 1998; 351:659-664. doi:10.1016/S0140-6736(97)09408-7Sohar E., Gafni J., Pras M., Heller H. Familial Mediterranean fever: a survey of 470 cases and review of the literature. Am J Med 1967; 43:227-253. doi:10.1016/0002-9343(67)90167-2Sohar E., Gafni J., Pras M., Heller H. Familial Mediterranean fever: a survey of 470 cases and review of the literature. Am J Med 1967; 43:227-253. doi:10.1016/0002-9343(67)90167-2Goldfinger S.E. Colchicine for familial Mediterranean fever. N Eng J Med. 1972;287:1302. doi:10.1056/NEJM197212212872514Goldfinger S.E. Colchicine for familial Mediterranean fever. N Eng J Med. 1972;287:1302. doi:10.1056/NEJM197212212872514Taylor E. W. The mechanism of colchicine inhibition of mitosis. Kinetics of Inhibition and the Binding of H3-Colchicine. J Cell Biol.1965;25(1):145-160. doi:10.1083/jcb.25.1.145Taylor E. W. The mechanism of colchicine inhibition of mitosis. Kinetics of Inhibition and the Binding of H3-Colchicine. J Cell Biol.1965;25(1):145-160. doi:10.1083/jcb.25.1.145Ehrenfeld E.N., Polishuk W.Z. Gynecological aspects of recurrent polyserositis. Isr J Med Sci. 1970; 6:9-13.Ehrenfeld E.N., Polishuk W.Z. Gynecological aspects of recurrent polyserositis. Isr J Med Sci. 1970; 6:9-13.Mamou H. Periodic Disease and Endocrine Disorders. Semin Hop Paris.1970;46:2027-2029.Mamou H. Periodic Disease and Endocrine Disorders. Semin Hop Paris.1970;46:2027-2029.Ismajovich B., Zemer D., Revach M. et al. The causes of infertility in females with familial editerranean fever. Fertil Steril.1973;24:844-847. doi:10.1016/s0015-0282(16)40030-0Ismajovich B., Zemer D., Revach M. et al. The causes of infertility in females with familial editerranean fever. Fertil Steril.1973;24:844-847. doi:10.1016/s0015-0282(16)40030-0Ben-Chetrit E., Ben-Chetrit A., Berkun Y., Ben-Chetrit E. Pregnancy outcomes in women with familial Mediterranean fever receiving colchicine: is amniocentesis justified? Arthritis Care Res.2010; 62(2):143-148. doi:10.1002/acr.20061Ben-Chetrit E., Ben-Chetrit A., Berkun Y., Ben-Chetrit E. Pregnancy outcomes in women with familial Mediterranean fever receiving colchicine: is amniocentesis justified? Arthritis Care Res.2010; 62(2):143-148. doi:10.1002/acr.20061Yanmaz M.N., Özcan A.J., Savan K. The impact of familial Mediterranean fever on reproductive system. Clin Rheumatol. 2014;33(10):1385-1388. doi:10.1007/s10067-014-2709-9Yanmaz M.N., Özcan A.J., Savan K. The impact of familial Mediterranean fever on reproductive system. Clin Rheumatol. 2014;33(10):1385-1388. doi:10.1007/s10067-014-2709-9Sarı İ., Birlik M., Kasifoğlu T. Familial Mediterranean fever: An updated review. Eur J Rheumatol. 2014;1(1):21-33. doi:10.5152/eurjrheum.2014.006Sarı İ., Birlik M., Kasifoğlu T. Familial Mediterranean fever: An updated review. Eur J Rheumatol. 2014;1(1):21-33. doi:10.5152/eurjrheum.2014.006Dotters-Katz S., Kuller J., Price T. The impact of familial Mediterranean fever on women’s health. Obstet Gynecol Surv. 2012;67(6):357-364. doi:10.1097/OGX.0b013e318259ed3aDotters-Katz S., Kuller J., Price T. The impact of familial Mediterranean fever on women’s health. Obstet Gynecol Surv. 2012;67(6):357-364. doi:10.1097/OGX.0b013e318259ed3aIndraratna P., Virk S., Gurram D., Day R. Use of colchicine in pregnancy: A systematic review and meta-analysis. Rheumatology (Oxford) 2018; 57(2):382-387. doi:10.1093/rheumatology/kex353.Indraratna P., Virk S., Gurram D., Day R. Use of colchicine in pregnancy: A systematic review and meta-analysis. Rheumatology (Oxford) 2018; 57(2):382-387. doi:10.1093/rheumatology/kex353.Granat M., Tur-Kaspa I., Zylber-Katz E., Schenker J.G. Reduction of peritoneal adhesion formation by colchicine: a comparative study in the rat. Fertil Steril 1983; 40:369-372. doi:10.1016/s0015-0282(16)47302-4.Granat M., Tur-Kaspa I., Zylber-Katz E., Schenker J.G. Reduction of peritoneal adhesion formation by colchicine: a comparative study in the rat. Fertil Steril 1983; 40:369-372. doi:10.1016/s0015-0282(16)47302-4.Ben-Chetrit E., Levy M. Reproductive system in familial Mediterranean fever: an overview. Ann Rheum Dis 2003; 62:916-919. doi: 10.1136/ard.62.10.916.Ben-Chetrit E., Levy M. Reproductive system in familial Mediterranean fever: an overview. Ann Rheum Dis 2003; 62:916-919. doi: 10.1136/ard.62.10.916.Ben-Chetrit E. Clinical manifestations and diagnosis of familial Mediterranean fever. Available at: https://www.uptodate.com/contents/clinical-manifestations-and-diagnosis-of-familial-mediterranean-fever/printBen-Chetrit E. Clinical manifestations and diagnosis of familial Mediterranean fever. Available at: https://www.uptodate.com/contents/clinical-manifestations-and-diagnosis-of-familial-mediterranean-fever/printFrench FMFC. A candidate gene for Familial Mediterranean Fever. Nat Genet 1997;17:25-31. doi:10.1038/ng0997-25.French FMFC. A candidate gene for Familial Mediterranean Fever. Nat Genet 1997;17:25-31. doi:10.1038/ng0997-25.The International FMF Consortium. Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever. Cell 1997; 90:797-807. doi: 10.1016/s0092-8674(00)80539-5.The International FMF Consortium. Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever. Cell 1997; 90:797-807. doi: 10.1016/s0092-8674(00)80539-5.de Menthière С.S., Terrière S., Pugnère D., Ruiz M., Demaille J., Touitou I. INFEVERS: the Registry for FMF and hereditary inflammatory disorders mutations/ Nucleic Acids Research 2003; 31(1): 282-285. https://doi.org/10.1093/nar/gkg031de Menthière С.S., Terrière S., Pugnère D., Ruiz M., Demaille J., Touitou I. INFEVERS: the Registry for FMF and hereditary inflammatory disorders mutations/ Nucleic Acids Research 2003; 31(1): 282-285. https://doi.org/10.1093/nar/gkg031Ozdogan H., Ugurlu S. Familial Mediterranean Fever. Presse Med. 2019;48(1):61-76. doi:10.1016/j.lpm.2018.08.014.Ozdogan H., Ugurlu S. Familial Mediterranean Fever. Presse Med. 2019;48(1):61-76. doi:10.1016/j.lpm.2018.08.014.Touitou I. The spectrum of Familial Mediterranean Fever (FMF) mutations. Eur J Hum Gen 2001;9(7):473-483. doi:10.1038/sj.ejhg.5200658.Touitou I. The spectrum of Familial Mediterranean Fever (FMF) mutations. Eur J Hum Gen 2001;9(7):473-483. doi:10.1038/sj.ejhg.5200658.Shinar Y., Obici L., Aksentijevich I., Sarkisian T. Guidelines for the genetic diagnosis of hereditary recurrent fevers. Ann Rheum Dis. 2012;71(10):1599-1605. doi: 10.1136/annrheumdis-2011-201271Shinar Y., Obici L., Aksentijevich I., Sarkisian T. Guidelines for the genetic diagnosis of hereditary recurrent fevers. Ann Rheum Dis. 2012;71(10):1599-1605. doi: 10.1136/annrheumdis-2011-201271Gershoni-Baruch R., Вrik R., Shinawi M., Livneh A. The differential contribution of MEFV mutant alleles to the clinical profile of Familial Mediterranean Fever. Eur J Hum Genet 2002;10(2):145-149. doi:10.1038/sj.ejhg.5200776.Gershoni-Baruch R., Вrik R., Shinawi M., Livneh A. The differential contribution of MEFV mutant alleles to the clinical profile of Familial Mediterranean Fever. Eur J Hum Genet 2002;10(2):145-149. doi:10.1038/sj.ejhg.5200776.Mijatovic V., Hompes P.G., Wouters M.G. Familial Mediterranean fever and its implications for fertility and pregnancy. Eur J Obstet Gynecol Reprod Biol 2003.10;108(2):171-176. doi:10.1016/s0301-2115(02)00417-7.Mijatovic V., Hompes P.G., Wouters M.G. Familial Mediterranean fever and its implications for fertility and pregnancy. Eur J Obstet Gynecol Reprod Biol 2003.10;108(2):171-176. doi:10.1016/s0301-2115(02)00417-7.Cerquaglia C., Verrecchia E., Fonnesu C. et al. Female reproductive dysfunction in familial Mediterranean fever patients with and without colchicine treatment. Clin Exp Rheumatol 2010;28:S101.Cerquaglia C., Verrecchia E., Fonnesu C. et al. Female reproductive dysfunction in familial Mediterranean fever patients with and without colchicine treatment. Clin Exp Rheumatol 2010;28:S101.Ofir D., Levy A., Wiznitzer A. et al. Familial Mediterranean fever during pregnancy: an independent risk factor for preterm delivery. Eur J Obstet Gynecol Reprod Biol 2008; 141:115-118. doi:10.1016/j.ejogrb.2008.07.025.Ofir D., Levy A., Wiznitzer A. et al. Familial Mediterranean fever during pregnancy: an independent risk factor for preterm delivery. Eur J Obstet Gynecol Reprod Biol 2008; 141:115-118. doi:10.1016/j.ejogrb.2008.07.025.Golden R.L., Weigers E.W., Meagher J.G. Periodic fever and menses. Am J Obstet Gynecol 1973; 117:855-856.Golden R.L., Weigers E.W., Meagher J.G. Periodic fever and menses. Am J Obstet Gynecol 1973; 117:855-856.Ben-Chetrit E& Ben-Chetrit A. Familial Mediterranean fever and menstruation. BJOG: an international journal of obstetrics and gynaecology. 2001;108:403-407. doi:10.1111/j.1471-0528.2001.00083.x.Ben-Chetrit E& Ben-Chetrit A. Familial Mediterranean fever and menstruation. BJOG: an international journal of obstetrics and gynaecology. 2001;108:403-407. doi:10.1111/j.1471-0528.2001.00083.x.Koh K.K., Bui M.N., Mincemoyer R., Cannon R.O. 3rd. Effects of hormone therapy on inflammatory cell adhesion molecules in postmenopausal healthy women. Am J Cardiol 1997;80:1505-1507.Koh K.K., Bui M.N., Mincemoyer R., Cannon R.O. 3rd. Effects of hormone therapy on inflammatory cell adhesion molecules in postmenopausal healthy women. Am J Cardiol 1997;80:1505-1507.Chaudoreille M.M., Peyrot V., Braquer D. et al. Qualitative study of the interaction mechanism of estrogenic drugs with tubulin.… Biochem Pharmacol 1991March 1;41(5):685-693.Chaudoreille M.M., Peyrot V., Braquer D. et al. Qualitative study of the interaction mechanism of estrogenic drugs with tubulin.… Biochem Pharmacol 1991March 1;41(5):685-693.Levy M., Yaffe C. Testicular function in patients with familial Mediterranean fever on long-term colchicine treatment. Fertil Steril 1978; 29:667-668.doi:10.1016/s0015-0282(16)43342-x.Levy M., Yaffe C. Testicular function in patients with familial Mediterranean fever on long-term colchicine treatment. Fertil Steril 1978; 29:667-668.doi:10.1016/s0015-0282(16)43342-x.Cronstein B.N., Molad Y., Reibman J. et al. Colchicine alters the quantitative and qualitative display of selectins on endothelial cells and neutrophils. J Clin Invest 1995; 96:994-1002. doi:10.1172/JCI118147.Cronstein B.N., Molad Y., Reibman J. et al. Colchicine alters the quantitative and qualitative display of selectins on endothelial cells and neutrophils. J Clin Invest 1995; 96:994-1002. doi:10.1172/JCI118147.Ben-Chetrit E., Levy M. Colchicine update 1998. Semin Arthritis Rheum 1998;28:48-59. doi:10.1016/s0049-0172(98)80028-0.Ben-Chetrit E., Levy M. Colchicine update 1998. Semin Arthritis Rheum 1998;28:48-59. doi:10.1016/s0049-0172(98)80028-0.Ehrenfeld M., Brzezinski A., Levy M., Eliakim M. Fertility and obstetric history in patients with familial Mediterranean fever on long term colchicines therapy. Br J Obstet Gynaecol 1987; 94:1186-1191. doi:10.1111/j.1471-0528. 1987. Tb 02320.x.Ehrenfeld M., Brzezinski A., Levy M., Eliakim M. Fertility and obstetric history in patients with familial Mediterranean fever on long term colchicines therapy. Br J Obstet Gynaecol 1987; 94:1186-1191. doi:10.1111/j.1471-0528. 1987. Tb 02320.x.Dor J., Homburg R., Rabau E. An evaluation of etiologic factors and therapies in 665 infertile couples. Fertil Steril 1977;28:718-722.Dor J., Homburg R., Rabau E. An evaluation of etiologic factors and therapies in 665 infertile couples. Fertil Steril 1977;28:718-722.Uzunaslan D., Saygin C., Hatemi G. et al. No appreciable decrease in fertility in Behçet’s syndrome. Rheumatology (Oxford) 2014;53(5):828-833. doi:10.1093/rheumatology/ket436.Uzunaslan D., Saygin C., Hatemi G. et al. No appreciable decrease in fertility in Behçet’s syndrome. Rheumatology (Oxford) 2014;53(5):828-833. doi:10.1093/rheumatology/ket436.Zadeh N., Getzug T., Grody W.W. Diagnosis and management of familial Mediterranean fever: Integrating medical genetics in a dedicated interdisciplinary clinic. Genet Med 2011;13(3):263-269. doi:10.1097/GIM.0b013e31820e27b1.Zadeh N., Getzug T., Grody W.W. Diagnosis and management of familial Mediterranean fever: Integrating medical genetics in a dedicated interdisciplinary clinic. Genet Med 2011;13(3):263-269. doi:10.1097/GIM.0b013e31820e27b1.Haimov-Kochman R., Prus D., Ben-Chetrit E. Azoospermia due to testicular amyloidosis in a patient with familial Mediterranean fever. Hum Reprod 2001;16:1218-1220. doi:10.1093/humrep/16.6.1218.Haimov-Kochman R., Prus D., Ben-Chetrit E. Azoospermia due to testicular amyloidosis in a patient with familial Mediterranean fever. Hum Reprod 2001;16:1218-1220. doi:10.1093/humrep/16.6.1218.Shepard T.H. Catalog of teratogenic agents, 6th ed. Baltimore, MD: Johns Hopkins University Press; 1989:164-166.Shepard T.H. Catalog of teratogenic agents, 6th ed. Baltimore, MD: Johns Hopkins University Press; 1989:164-166.Merlin H.E. Azoospermia caused by colchicine - a case report. Fertil Steril 1972; 23:180-181. doi:10.1016/s0015-0282(16)38823-9.Merlin H.E. Azoospermia caused by colchicine - a case report. Fertil Steril 1972; 23:180-181. doi:10.1016/s0015-0282(16)38823-9.Yu T.F., Gutman A.B. Efficacy of colchicine prophylaxis in gout. Ann Int Med 1961;55:179-192. doi:10.7326/0003-4819-55-2-179.Yu T.F., Gutman A.B. Efficacy of colchicine prophylaxis in gout. Ann Int Med 1961;55:179-192. doi:10.7326/0003-4819-55-2-179.Bremner W.J., Plausen C.A. Colchicine and testicular function in man. N Eng J Med 1976; 294:1384-1385. doi:10.1056/NEJM197606172942508.Bremner W.J., Plausen C.A. Colchicine and testicular function in man. N Eng J Med 1976; 294:1384-1385. doi:10.1056/NEJM197606172942508.Sarica K., Suzer O., Gurler A. et al. Urological evaluation of Behcet patients and the effect of colchicine on fertility. Eur J Urol 1995; 22:39-42. doi:10.1159/000475121.Sarica K., Suzer O., Gurler A. et al. Urological evaluation of Behcet patients and the effect of colchicine on fertility. Eur J Urol 1995; 22:39-42. doi:10.1159/000475121.Ben-Chetrit E., Backenroth R., Haimov-Kochman R., Pizov G. Azoospermia in familial Mediterranean fever patients: the role of colchicines and amyloidosis. Ann Rheum Dis 1998; 57:259-260. doi:10.1136/ard.57.4.259Ben-Chetrit E., Backenroth R., Haimov-Kochman R., Pizov G. Azoospermia in familial Mediterranean fever patients: the role of colchicines and amyloidosis. Ann Rheum Dis 1998; 57:259-260. doi:10.1136/ard.57.4.259Ben-Chetrit A., Ben-Chetrit E., Nitzan R., Ron M. Colchicine inhibits human spermatozoal motility in-vitro. Inter J Fertil 1993;88:301-304.Ben-Chetrit A., Ben-Chetrit E., Nitzan R., Ron M. Colchicine inhibits human spermatozoal motility in-vitro. Inter J Fertil 1993;88:301-304.Zemer D., Pras M., Shemer Y. Daily prophylactic colchicine in familial Mediterranean fever. In: Amyloid and Amyloidosis. Proceedings of the 3rd International Symposium on Amyloidosis. ExerptaMedica. Amsterdam-Oxford-Prinston. 1980:580-583.Zemer D., Pras M., Shemer Y. Daily prophylactic colchicine in familial Mediterranean fever. In: Amyloid and Amyloidosis. Proceedings of the 3rd International Symposium on Amyloidosis. ExerptaMedica. Amsterdam-Oxford-Prinston. 1980:580-583.Ben-Chetrit E., Berkun Y., Ben-Chetrit E., Ben-Chetrit A. The outcome of pregnancy in the wives of men with familial mediterranean fever treated with colchicine. Semin Arthritis Rheum 2004 Oct;34(2):549-552. doi:10.1016/j.semarthrit.2004.07.004.Ben-Chetrit E., Berkun Y., Ben-Chetrit E., Ben-Chetrit A. The outcome of pregnancy in the wives of men with familial mediterranean fever treated with colchicine. Semin Arthritis Rheum 2004 Oct;34(2):549-552. doi:10.1016/j.semarthrit.2004.07.004.Ugurlu S., Seyahi E., Hatemi G. et al. Canakinumab Therapy in Patients with Familial Mediterranean Fever. Arthritis Rheumatol 2015;67:362-363Ugurlu S., Seyahi E., Hatemi G. et al. Canakinumab Therapy in Patients with Familial Mediterranean Fever. Arthritis Rheumatol 2015;67:362-363Youngstein T., Hoffman P., Gul A. et al. International multi-centre study of pregnancy outcomes with interleukin-1 inhibitors. Rheumatology 2017;456:2102-2108. doi:10.1093/rheumatology/ kex305.Youngstein T., Hoffman P., Gul A. et al. International multi-centre study of pregnancy outcomes with interleukin-1 inhibitors. Rheumatology 2017;456:2102-2108. doi:10.1093/rheumatology/ kex305.Yilmaz N.K., Kara M., Kaba M. et al. Effect of Familial Mediterranean Fever on IVF outcome: A Retrospective Case Series. Acta Clin Croat 2016;55:254-258. doi:10.20471/acc.2016.55.02.11.Yilmaz N.K., Kara M., Kaba M. et al. Effect of Familial Mediterranean Fever on IVF outcome: A Retrospective Case Series. Acta Clin Croat 2016;55:254-258. doi:10.20471/acc.2016.55.02.11.Ozgur K., Bulut H., Berkkanoglu M. et al. Colchicine treatment for FMF does not affect IVF outcome. Fertility and Sterility 2013;100(3):S507. doi:https://doi.org/10.1016/j.fertnstert. 2013.07.205Ozgur K., Bulut H., Berkkanoglu M. et al. Colchicine treatment for FMF does not affect IVF outcome. Fertility and Sterility 2013;100(3):S507. doi:https://doi.org/10.1016/j.fertnstert. 2013.07.205Diav-Citrin O., Shechtman S., Schwartz V. et al. Pregnancy outcome after in utero exposure to colchicine. Am J Obstet Gynecol. 2010; 203:144. doi:10.1016/j.ajog.2010.02.063.Diav-Citrin O., Shechtman S., Schwartz V. et al. Pregnancy outcome after in utero exposure to colchicine. Am J Obstet Gynecol. 2010; 203:144. doi:10.1016/j.ajog.2010.02.063.Oner G., Muderris I.I. Assessment of ovarian reserve based on hormonal parameters, ovarian volume, and antral follicle count in women with familial Mediterranean fever. Eur J Obstet Gynecol Reprod Biol 2013. Oct;170(2):449-451. doi:10.1016/j.ejogrb.2013.07.023.Oner G., Muderris I.I. Assessment of ovarian reserve based on hormonal parameters, ovarian volume, and antral follicle count in women with familial Mediterranean fever. Eur J Obstet Gynecol Reprod Biol 2013. Oct;170(2):449-451. doi:10.1016/j.ejogrb.2013.07.023.Ozen S., Demirkaya E., Erer B. et al. EULAR recommendations for the management of familial Mediterranean fever. Annals of the Rheumatic Diseases 2016;75:644-651. doi:10.1136/ annrheumdis-2015-208690.Ozen S., Demirkaya E., Erer B. et al. EULAR recommendations for the management of familial Mediterranean fever. Annals of the Rheumatic Diseases 2016;75:644-651. doi:10.1136/ annrheumdis-2015-208690.

The authors declare that there are no conflicts of interest present.