medgenМедицинская генетикаMedical Genetics2073-7998Publishing House «Genius Media» LLC10.25557/2073-7998.2020.11.54-57medgen-1796Research ArticleКРАТКИЕ СООБЩЕНИЯBRIEF REPORTЧастота микроделеций Y-хромосомы у армянских мужчин с бесплодиемFrequency of Y chromosome microdeletions in Armenian infertile menШахсуварянГ. Р.ShahsuvaryanG. .gshahsuvaryan@gmail.comКараханянР. .KarakhanyanR. .noemail@neicon.ruСаркисянТ. Ф.SarkisianT. .noemail@neicon.ruИжевскаяВ. Л.IzhevskayaV. .noemail@neicon.ruЦентр медицинской гeнетики и первичной охраны здоровьяРоссияCenter of Medical Genetics and Primary Health CareRussian FederationФГБНУ «Медико-генетический научный центр имени академика Н.П. Бочкова»РоссияResearch Centre for Medical GeneticsRussian Federation20200202202119115457Copyright © Шахсуварян Г.Р., Караханян Р..., Саркисян Т.Ф., Ижевская В.Л., 20212021Шахсуварян Г.Р., Караханян Р..., Саркисян Т.Ф., Ижевская В.Л.Shahsuvaryan G..., Karakhanyan R..., Sarkisian T..., Izhevskaya V...Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medgen-journal.ru/jour/article/view/1796

Микроделеции длинного плеча Y-хромосомы являются частой генетической причиной мужского бесплодия, связанного с азооспермией и олигозооспермией. В различных этнических группах частота встречаемости микроделеций Y-хромосомы может существенно варьировать, а их спектр иметь определенные особенности. Целью представленного исследования являлось определение частоты и структуры микроделеционных изменений локуса AZF у мужчин армянской национальности с бесплодием для оптимизации диагностических и лечебных мероприятий с применением вспомогательных репродуктивных технологий.

The long arm of the Y chromosome microdeletions are common genetic cause of male infertility, related with azoospermia and oligozoospermia. The frequency of various Y-chromosome microdeletions can vary significantly in different ethnic groups and have certain features. The aim of the presented research is to determine the frequency and spectrum of AZF (azoospermia factor) microdeletions in infertile men of Armenian nationality, in order to optimize diagnostic and therapeutic measures using assisted reproductive technologies.

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The authors declare that there are no conflicts of interest present.