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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medgen</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинская генетика</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Genetics</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2073-7998</issn><publisher><publisher-name>Publishing House «Genius Media» LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">medgen-1727</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КРАТКИЕ СООБЩЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>BRIEF REPORT</subject></subj-group></article-categories><title-group><article-title>Способность мелаксена модифицировать кластогенные эффекты кадмия в костном мозге крыс</article-title><trans-title-group xml:lang="en"><trans-title>Modification of the clastogenic effects of cadmium in rat bone marrow with the melaxen</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чшиева</surname><given-names>Ф. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Chshieva</surname><given-names>F. T.</given-names></name></name-alternatives><email xlink:type="simple">fa-2009@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чшиев</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Chshiev</surname><given-names>T. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кокаев</surname><given-names>Р. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Kokaev</surname><given-names>R. I.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Северо-Осетинская государственная медицинская академия</institution><country>Россия</country></aff><aff xml:lang="en"><institution>North Ossetian state medical Academy</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Институт биомедицинских исследований Владикавказского научного центра РАН</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Institute of biomedical research VSC RAS</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>26</day><month>11</month><year>2020</year></pub-date><volume>19</volume><issue>9</issue><fpage>103</fpage><lpage>104</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Чшиева Ф.Т., Чшиев Т.В., Кокаев Р.И., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Чшиева Ф.Т., Чшиев Т.В., Кокаев Р.И.</copyright-holder><copyright-holder xml:lang="en">Chshieva F.T., Chshiev T.V., Kokaev R.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.medgen-journal.ru/jour/article/view/1727">https://www.medgen-journal.ru/jour/article/view/1727</self-uri><abstract><p>При хроническом применении мелаксена в дозе 10 мг/кг индукции генотоксических эффектов в костном мозге крыс не выявлено. Метафазный анализ после хронического совместного внутрижелудочного введения соли кадмия 0,3 мг/кг (в пересчете на металл) и мелаксена показал протекторные свойства последнего (р&lt;0,01).</p></abstract><trans-abstract xml:lang="en"><p>There was no reveled induction of genotoxic effects in rat bone marrow at the constant use of “melaxen” at a dose of 10 mg/kg. The chronic joint intragastric injection of a cadmium salt of 0.3 mg / kg (in terms of metal) and “melaxen “ showed the protective properties of the remedy (p&lt;0.01) after metaphase analysis.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>хромосомные аберрации</kwd><kwd>мелаксен</kwd><kwd>кластогенез</kwd><kwd>антимутагенез</kwd><kwd>кадмий</kwd></kwd-group><kwd-group xml:lang="en"><kwd>chromosomal aberrations</kwd><kwd>melaxen</kwd><kwd>clastogenesis</kwd><kwd>antimutagenesis</kwd><kwd>cadmium</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
