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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medgen</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинская генетика</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Genetics</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2073-7998</issn><publisher><publisher-name>Publishing House «Genius Media» LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">medgen-1722</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КРАТКИЕ СООБЩЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>BRIEF REPORT</subject></subj-group></article-categories><title-group><article-title>Молекулярный ответ фибробластов кожи человека с мутацией m. 14441 T&gt;C на воздействие ионизирующего излучения в малых и средних дозах</article-title><trans-title-group xml:lang="en"><trans-title>Molecular response of human skin fibroblasts with a mutation m. 14441 T&gt;C on the action of ionizing radiation in low and medium doses</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Абрамова</surname><given-names>М. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Abramova</surname><given-names>M. S.</given-names></name></name-alternatives><email xlink:type="simple">rimargarii@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Конькова</surname><given-names>М. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Konkova</surname><given-names>M. S.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Момот</surname><given-names>В. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Momot</surname><given-names>V. U.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кальянов</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kalyanov</surname><given-names>A. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Медико-генетический научный центр имени академика Н. П. Бочкова»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Centre for Medical Genetics</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГАОУ ВО Первый МГМУ имени И.М. Сеченова Минздрава России (Сеченовский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>26</day><month>11</month><year>2020</year></pub-date><volume>19</volume><issue>9</issue><fpage>91</fpage><lpage>93</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Абрамова М.С., Конькова М.С., Момот В.Ю., Кальянов А.А., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Абрамова М.С., Конькова М.С., Момот В.Ю., Кальянов А.А.</copyright-holder><copyright-holder xml:lang="en">Abramova M.S., Konkova M.S., Momot V.U., Kalyanov A.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.medgen-journal.ru/jour/article/view/1722">https://www.medgen-journal.ru/jour/article/view/1722</self-uri><abstract><p>В качестве модели для исследования были выбраны фибробласты с мутацией m.14441 T&gt;C в гене ND6 и фибробласты здорового донора. Было показано, что данная мутация в гене ND6 митохондриальной ДНК (мтДНК) оказывает значительное влияние на ответ клеток во время окислительного стресса.</p></abstract><trans-abstract xml:lang="en"><p>Fibroblasts with the mutation of m.14441 T&gt;C in the ND6 gene and fibroblasts of a healthy donor were chosen as a research model. It was shown that this mutation in the ND6 mitochondrial DNA gene has a significant effect on the cellular response during oxidative stress.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>митохондриальная ДНК</kwd><kwd>малые дозы радиации</kwd><kwd>средние дозы радиации</kwd><kwd>окислительный стресс</kwd></kwd-group><kwd-group xml:lang="en"><kwd>mitochondrial DNA</kwd><kwd>low radiation doses</kwd><kwd>medium radiation doses</kwd><kwd>oxidative stress</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
