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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medgen</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинская генетика</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Genetics</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2073-7998</issn><publisher><publisher-name>Publishing House «Genius Media» LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">medgen-1686</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КРАТКИЕ СООБЩЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>BRIEF REPORT</subject></subj-group></article-categories><title-group><article-title>Исследование молекулярно-генетических основ остеоартрита у женщин с недифференцированной дисплазией соединительной ткани из Республики Башкортостан</article-title><trans-title-group xml:lang="en"><trans-title>Study of genetic predisposition to osteoarthritis in women with connective tissue dysplasia from the Republic of Bashkortostan</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шаповалова</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Shapovalova</surname><given-names>D. A.</given-names></name></name-alternatives><email xlink:type="simple">daria-ufa92@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тюрин</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Tyurin</surname><given-names>A. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хусаинова</surname><given-names>Р. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Khusainova</surname><given-names>R. I.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Институт биохимии и генетики УФИЦ РАН</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Institute of Biochemistry and Genetics of the Ufa Federal Research Centre RAS</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГОУВПО «Башкирский государственный медицинский университет»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Bashkir State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Институт биохимии и генетики УФИЦ РАН;  ГОУВПО «Башкирский государственный медицинский университет»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Institute of Biochemistry and Genetics of the Ufa Federal Research Centre RAS</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>26</day><month>11</month><year>2020</year></pub-date><volume>19</volume><issue>8</issue><fpage>67</fpage><lpage>69</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шаповалова Д.А., Тюрин А.В., Хусаинова Р.И., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Шаповалова Д.А., Тюрин А.В., Хусаинова Р.И.</copyright-holder><copyright-holder xml:lang="en">Shapovalova D.A., Tyurin A.V., Khusainova R.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.medgen-journal.ru/jour/article/view/1686">https://www.medgen-journal.ru/jour/article/view/1686</self-uri><abstract><p>Остеоартрит (ОА) - наиболее распространенное многофакторное заболевание суставов. Одним из вероятных факторов риска развития ОА является недифференцированная дисплазия соединительной ткани (нДСТ) - генетически детерминированное нарушение структуры соединительной ткани, в том числе и в суставах. Вопрос о коморбидности ОА с нДСТ чрезвычайно актуален, и решение данной задачи будет способствовать разработке подходов ранней диагностики ОА в целях профилактики заболевания.</p></abstract><trans-abstract xml:lang="en"><p>Osteoarthritis (OA) is a common multifactorial joint disease. Undifferentiated connective tissue dysplasia (uCTD) is a genetically determined lesion of the connective tissue structures, including joints, and it can be one of the factors, predisposing to development of OA. Solving the problem of comorbidity OA and uCTD signs will contribute to the early diagnosis and preventive of OA.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>остеоартрит</kwd><kwd>дисплазия соединительной ткани</kwd><kwd>полиморфные локусы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>osteoarthritis</kwd><kwd>connective tissue dysplasia</kwd><kwd>polymorphic loci</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
