medgenМедицинская генетикаMedical Genetics2073-7998Publishing House «Genius Media» LLC10.1234/XXXX-XXXX-2016-8-46-48medgen-166Research ArticleСтатьиПолиморфизм генов STAT4 и CTLA4 у населения Беларуси в связи с предрасположенностью к заболеванию ювенильным идиопатическим артритомSTAT4 and CTLA4 genes polymorphism in Belarusian population in view of predisposition to juvenile idiopathic arthritisЯцкивА. А.YatskivA. A.noemail@neicon.ruНикитченкоН. В.NikitchenkoN. V.noemail@neicon.ruЧичкоА. М.ChichkoA. M.noemail@neicon.ruСукалоА. В.SukaloA. V.noemail@neicon.ruГончароваР. И.GoncharovaR. I.RGoncharova@igc.byИнститут генетики и цитологии НАН БеларусиРоссияInstitute of Genetics and Cytology of NAS of BelarusRussian FederationУО «Белорусский государственный медицинский университет»РоссияBelarusian State Medical UniversityRussian Federation2016071020161584648Copyright © Яцкив А.А., Никитченко Н.В., Чичко А.М., Сукало А.В., Гончарова Р.И., 20162016Яцкив А.А., Никитченко Н.В., Чичко А.М., Сукало А.В., Гончарова Р.И.Yatskiv A.A., Nikitchenko N.V., Chichko A.M., Sukalo A.V., Goncharova R.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medgen-journal.ru/jour/article/view/166

Генотипирование по полиморфным локусам G/T rs7574865 гена STAT4 и C/T rs5742909 гена CTLA4 не показало статистически достоверных различий в распределении частот аллелей и генотипов при сравнении групп с диагнозом ювенильный идиопатический артрит (ЮИА) (n = 80) и контроля (n = 80). В то же время, после стратификации по подтипам заболевания, для полиморфизма G/T rs7574865 гена STAT4 отмечена ассоциация мутантного аллеля Т с полиартикулярным ЮИА. Для выяснения точной роли изучаемых полиморфных локусов в предрасположенности к ЮИА необходимо увеличение количества индивидов в исследуемых когортах.

Genotyping of STAT4 gene rs7574865 and CTLA4 gene rs5742909 variants hasn’t shown any statistically significant differences in the allele and genotype frequency distribution when comparing groups of JIA patients (n = 80) and controls (n = 80). However, after stratification by JIA subtype the T allele of rs7574865 variant of STAT4 gene was associated with polyarticular JIA. To clarify the exact role of the polymorphisms studied in predisposition to JIA, extension of investigated groups sample size is required.

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The authors declare that there are no conflicts of interest present.