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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medgen</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинская генетика</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Genetics</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2073-7998</issn><publisher><publisher-name>Publishing House «Genius Media» LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">medgen-1396</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КРАТКИЕ СООБЩЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>BRIEF REPORT</subject></subj-group></article-categories><title-group><article-title>Скрининг варианта сайта сплайсинга в гене CDK12 у больных раком яичников</article-title><trans-title-group xml:lang="en"><trans-title>Screening for a variant of the splicing site in the CDK12 gene in patients with ovarian cancer</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Валова</surname><given-names>Я. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Valova</surname><given-names>Ya. V.</given-names></name></name-alternatives><email xlink:type="simple">q.juk@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Муллагалеева</surname><given-names>Э. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Mullagaleeva</surname><given-names>E. F.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мингажева</surname><given-names>Э. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Mingazheva</surname><given-names>E. T.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Прокофьева</surname><given-names>Д. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Prokofyeva</surname><given-names>D. S.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Нургалиева</surname><given-names>А. Х.</given-names></name><name name-style="western" xml:lang="en"><surname>Nurgalieva</surname><given-names>A. Kh.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фаисханова</surname><given-names>Р. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Faishanova</surname><given-names>R. R.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хуснутдинова</surname><given-names>Э. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Khusnutdinova</surname><given-names>E. K.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Башкирский государственный университет»; ФБУН «Уфимский НИИ медицины труда и экологии человека»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Bashkir State University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО «Башкирский государственный университет»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Bashkir State University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ГБУЗ «Республиканский клинический онкологический диспансер»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Republic Clinical Oncological Center of Bashkortostan Republic</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ФГБОУ ВО «Башкирский государственный университет»; ОСП ФГБНУ УФИЦ РАН «Институт биохимии и генетики»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Bashkir State University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>13</day><month>11</month><year>2020</year></pub-date><volume>19</volume><issue>6</issue><fpage>42</fpage><lpage>43</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Валова Я.В., Муллагалеева Э.Ф., Мингажева Э.Т., Прокофьева Д.С., Нургалиева А.Х., Фаисханова Р.Р., Хуснутдинова Э.К., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Валова Я.В., Муллагалеева Э.Ф., Мингажева Э.Т., Прокофьева Д.С., Нургалиева А.Х., Фаисханова Р.Р., Хуснутдинова Э.К.</copyright-holder><copyright-holder xml:lang="en">Valova Y.V., Mullagaleeva E.F., Mingazheva E.T., Prokofyeva D.S., Nurgalieva A.K., Faishanova R.R., Khusnutdinova E.K.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.medgen-journal.ru/jour/article/view/1396">https://www.medgen-journal.ru/jour/article/view/1396</self-uri><abstract><p>Рак яичников (РЯ) представляет собой важную проблему здравоохранения во всем мире. Данная онкопатология имеет самые высокие показатели смертности и самые низкие показатели выживаемости в течение первого года среди злокачественных опухолей женской репродуктивной системы. В связи с этим, разработка и усовершенствование методов ранней диагностики РЯ являются одной из приоритетных задач онкогинекологии. В настоящей работе представлен поиск ассоциаций варианта сайта сплайсинга c.1047-2A&gt; G в гене CDK12 с развитием рака яичников в Республики Башкортостан.</p></abstract><trans-abstract xml:lang="en"><p>Ovarian cancer (OV) is an important public health problem worldwide. This oncopathology has the highest mortality rates and the lowest survival rates during the first year among malignant tumors of the female reproductive system. In this regard, the development and improvement of methods for the early diagnosis of cancer is one of the priority tasks of gynecological oncology. This paper presents a search for associations of a variant of the splicing site c.1047-2A&gt; G in the CDK12 gene with the development of ovarian cancer in the Republic of Bashkortostan.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>рак яичников</kwd><kwd>гены-кандидаты</kwd><kwd>циклин зависимая киназа 12</kwd></kwd-group><kwd-group xml:lang="en"><kwd>ovarian cancer</kwd><kwd>candidate genes</kwd><kwd>cyclin-dependent kinase 12</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
