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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medgen</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинская генетика</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Genetics</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2073-7998</issn><publisher><publisher-name>Publishing House «Genius Media» LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">medgen-1394</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КРАТКИЕ СООБЩЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>BRIEF REPORT</subject></subj-group></article-categories><title-group><article-title>Полиморфизмы генов репарации LIG1 и LIG3 и риск развития рака молочной железы и рака яичников</article-title><trans-title-group xml:lang="en"><trans-title>LIG1 and LIG3 repair gene polymorphisms and the risk of developing breast and ovarian cancer</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бисултанова</surname><given-names>З. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Bisultanova</surname><given-names>Z. I.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Джамбетова</surname><given-names>П. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Dzhambetova</surname><given-names>P. M.</given-names></name></name-alternatives><email xlink:type="simple">petimat-lg@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Чеченский государственный университет»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Chechen State University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>13</day><month>11</month><year>2020</year></pub-date><volume>19</volume><issue>6</issue><fpage>38</fpage><lpage>39</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Бисултанова З.И., Джамбетова П.М., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Бисултанова З.И., Джамбетова П.М.</copyright-holder><copyright-holder xml:lang="en">Bisultanova Z.I., Dzhambetova P.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.medgen-journal.ru/jour/article/view/1394">https://www.medgen-journal.ru/jour/article/view/1394</self-uri><abstract><p>В выборке из 409 женщин с раком молочной железы и 60 с раком яичников из Чеченской республики исследованы ассоциации четырех функционально значимых полиморфизмов генов LIG1 и LIG3 (rs156641, rs20579, rs1052536, rs4796030) с заболеваниями. Генотипирование выполнено методом ПЦР-анализа. Выявлены кандидатные генотипы, которые влияют на риск развития рака молочной железы и рака яичников.</p></abstract><trans-abstract xml:lang="en"><p>The nature of the effect on the formation of breast cancer and the reproductive system in 409 women with breast cancer and 60 with cancer in the Chechen population of four functionally significant polymorphisms of the LIG1 and LIG3 genes (rs156641, rs20579, rs1052536, rs4796030) was studied. Genotyping was performed using PCR analysis. We identified the candidate genotypes that influence the risk of developing breast and ovarian cancer.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>полиморфизм генов репарации</kwd><kwd>LIG1</kwd><kwd>LIG3</kwd><kwd>rs156641</kwd><kwd>rs20579</kwd><kwd>rs1052536</kwd><kwd>rs4796030</kwd><kwd>рак молочной железы</kwd><kwd>рак яичников</kwd><kwd>чеченская популяция</kwd></kwd-group><kwd-group xml:lang="en"><kwd>repair gene polymorphism</kwd><kwd>LIG1</kwd><kwd>LIG3</kwd><kwd>rs156641</kwd><kwd>rs20579</kwd><kwd>rs1052536</kwd><kwd>rs4796030</kwd><kwd>breast cancer</kwd><kwd>ovarian cancer</kwd><kwd>Chechen population</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
