<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medgen</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинская генетика</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Genetics</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2073-7998</issn><publisher><publisher-name>Publishing House «Genius Media» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.25557/2073-7998.2020.05.58-59</article-id><article-id custom-type="elpub" pub-id-type="custom">medgen-1213</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КРАТКИЕ СООБЩЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>BRIEF REPORT</subject></subj-group></article-categories><title-group><article-title>Изучение генетической составляющей нарушения пищевого поведения в выборке якутов с ожирением</article-title><trans-title-group xml:lang="en"><trans-title>The study of the genetic component of eating behavior in a sample of obese Yakuts</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Павлова</surname><given-names>Н. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Pavlova</surname><given-names>N. I.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Куртанов</surname><given-names>Х. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kurtanov</surname><given-names>H. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дьяконова</surname><given-names>А. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Dyakonova</surname><given-names>A. T.</given-names></name></name-alternatives><email xlink:type="simple">dyakonovaa@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Соловьева</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Solovyova</surname><given-names>N. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сыдыкова</surname><given-names>Л. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sydykova</surname><given-names>L. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Александрова</surname><given-names>Т. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Alexandrova</surname><given-names>T. N.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Якутский научный центр комплексных медицинских проблем</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Yakut Scientific Centre for Complex Medical Problems</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>12</day><month>11</month><year>2020</year></pub-date><volume>19</volume><issue>5</issue><fpage>58</fpage><lpage>59</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Павлова Н.И., Куртанов Х.А., Дьяконова А.Т., Соловьева Н.А., Сыдыкова Л.А., Александрова Т.Н., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Павлова Н.И., Куртанов Х.А., Дьяконова А.Т., Соловьева Н.А., Сыдыкова Л.А., Александрова Т.Н.</copyright-holder><copyright-holder xml:lang="en">Pavlova N.I., Kurtanov H.A., Dyakonova A.T., Solovyova N.A., Sydykova L.A., Alexandrova T.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.medgen-journal.ru/jour/article/view/1213">https://www.medgen-journal.ru/jour/article/view/1213</self-uri><abstract><p>Характер питания коренных жителей Севера сменился с белково-липидного на углеводно-липидный. Среди них увеличилось число лиц, страдающих ожирением, обусловленном не только сменой характера питания, но и гиподинамией. Целью исследования является изучение генетической составляющей нарушения пищевого поведения в выборке якутов с ожирением. Всего в исследовании принял участие 191 человек якутской национальности, из них 100 пациентов страдающих ожирением различной степени тяжести (73 женщины и 27 мужчин), в качестве группы сравнения сформирована выборка людей с нормальными показателями ИМТ (&lt; 25) в количестве 91 человека (70 женщин и 21 мужчина). По результатам исследования, частота встречаемости мутантного аллеля А rs9939609 гена FTO во всей обследованной группе составила 27%, при этом доля лиц с генотипом АА составляла 9,4 %. Анализ распределения аллелей и генотипов полиморфизма rs27072 гена DAT1 показал преобладание предкового аллеля G (90,8 %) и генотипа GG (82,7 %) во всех обследованных группах.</p></abstract><trans-abstract xml:lang="en"><p>The nature of the nutrition of the inhabitants of the North is from lipo-lipid. Among them, the number of obese people increased, due not only to the variable nature of nutrition, but also to physical inactivity. The aim of the study is to study the genetic component of eating disorders. In total, 191 people took part in the study, of which 100 people suffer from obesity of varying severity (73 women and 27 men), which allows us to compare a sample of people with normal MMT ((25) in the amount of 91 people (70 women and 21 men). According to the results of studies, the frequency of occurrence of the mutant allele A of rs9939609 FTO gene in all the studied groups is 27%, while the AA genotype is only 9.4%. An analysis of the distribution of alleles and genotypes of rs27072 polymorphism of the DAT1 gene showed the predominance of the ancestral G allele (90.8%) and the GG genotype (82.7%) in all examined samples.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ожирение</kwd><kwd>ген FTO</kwd><kwd>ген DAT1</kwd><kwd>rs9939609</kwd><kwd>rs27072</kwd><kwd>ИМТ</kwd><kwd>пищевое поведение</kwd><kwd>obesity</kwd><kwd>FTO gene</kwd><kwd>DAT1 gene</kwd><kwd>rs9939609</kwd><kwd>rs27072</kwd><kwd>BMI</kwd><kwd>eating behavior</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
