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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medgen</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинская генетика</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Genetics</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2073-7998</issn><publisher><publisher-name>Publishing House «Genius Media» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.25557/2073-7998.2020.04.46-48</article-id><article-id custom-type="elpub" pub-id-type="custom">medgen-1150</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КРАТКИЕ СООБЩЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>BRIEF REPORT</subject></subj-group></article-categories><title-group><article-title>Интернет-зависимость у подростков: поиск генетических ассоциаций</article-title><trans-title-group xml:lang="en"><trans-title>Internet addiction in adolescents: the search for genetic associations</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Смольникова</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Smolnikova</surname><given-names>M. V.</given-names></name></name-alternatives><email xlink:type="simple">smarinv@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Терещенко</surname><given-names>С. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Tereshchenko</surname><given-names>S. Yu.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Научно-исследовательский институт медицинских проблем Севера ФИЦ КНЦ СО РАН</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Scientific Research Institute of Medical Problems of the North FRC KSC SB RAS</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>15</day><month>09</month><year>2020</year></pub-date><volume>19</volume><issue>4</issue><fpage>46</fpage><lpage>48</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Смольникова М.В., Терещенко С.Ю., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Смольникова М.В., Терещенко С.Ю.</copyright-holder><copyright-holder xml:lang="en">Smolnikova M.V., Tereshchenko S.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.medgen-journal.ru/jour/article/view/1150">https://www.medgen-journal.ru/jour/article/view/1150</self-uri><abstract><p>Стремительность распространения интернет-зависимости у подростков связана с возникновением проблемной зависимости от неконтролируемого мобильного доступа в сеть. Это делает актуальным проблему поиска молекулярно-генетических и психологических маркеров высокого риска развития интернет-зависимости. Целью работы было изучение распространенности различных по степени выраженности вариантов интернет-зависимости у подростков и распределения у них полиморфных вариантов генов COMT и CHRNA4. Выявлено, что CC генотип rs1044396 CHRNA4 ассоциирован с интернет-зависимостью у подростков: его распространенность прогрессивно увеличивается с тяжестью интернет-зависимости. Аллельный вариант Т имеет «защитный» эффект от тяжелой и неконтролируемой зависимости.</p></abstract><trans-abstract xml:lang="en"><p>The rapidity of the emergence and spread of Internet addiction in adolescent populations, combined with the amount of consumed content, is associated with the emergence of a problematic dependence on uncontrolled mobile access to the network. This makes the problem of searching for molecular genetic and psychological markers of high risk of developing Internet addiction relevant. The aim of the work was to study the prevalence of Internet-dependent variants of different degrees of severity in adolescents and the distribution of polymorphic variants of the COMT and CHRNA4 genes. It was revealed that the CC variant rs1044396 CHRNA4 is associated with Internet addiction in adolescents: its prevalence progressively increases with the severity of Internet addiction. Whereas the allelic variant T has a “protective” effect against severe and uncontrolled dependence.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>интернет-зависимость</kwd><kwd>генетическая предрасположенность</kwd><kwd>подростки</kwd><kwd>internet addiction</kwd><kwd>genetic predisposition</kwd><kwd>adolescents</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
