medgenМедицинская генетикаMedical Genetics2073-7998Publishing House «Genius Media» LLC10.1234/XXXX-XXXX-2016-4-25-28medgen-112Research ArticleМЕЖДУНАРОДНАЯ НАУЧНАЯ КОНФЕРЕНЦИЯ МОЛОДЫХ УЧЕНЫХ «АКТУАЛЬНЫЕ ПРОБЛЕМЫ МЕДИЦИНСКОЙ ГЕНЕТИКИ», 29-30 СЕНТЯБРЯ 2016 Г., Г.ТОМСКРепликация данных полногеномных анализов ассоциации атопического дерматита в Республике БашкортостанReplication analysis of genome wide studies of atopic dermatitis in the Republic of BashkortostanГималоваГ. Ф.GimalovaG. F.galiyagimalova@gmail.ruКарунасА. С.KarunasA. S.noemail@neicon.ruФедороваЮ. Ю.FedorovaY. Y.noemail@neicon.ruГуменнаяЭ. Р.GumennayaE. R.noemail@neicon.ruЛевашеваС. В.LevashovaS. V.noemail@neicon.ruЭткинаЭ. И.EtkinaE. I.noemail@neicon.ruХуснутдиноваЭ. К.KhusnutdinovaE. K.noemail@neicon.ruИнститут биохимии и генетики Уфимского научного центра Российской академии наукРоссияInstitute of Biochemistry and Genetics of Ufa Scientific Centre of the Russian Academy of ScienRussian FederationИнститут биохимии и генетики Уфимского научного центра Российской академии наук; Башкирский государственный университет; Bashkir State UniversityRussian FederationРеспубликанский кожно-венерологический диспансерРоссияDermatovenerological Dispensary of the Republic of BashkortostanRussian FederationБашкирский государственный медицинский университетРоссияBashkir State Medical UniversityRussian FederationИнститут биохимии и генетики Уфимского научного центра Российской академии наук; Башкирский государственный университет; Bashkir State UniversityРоссияInstitute of Biochemistry and Genetics of Ufa Scientific Centre of the Russian Academy of ScienRussian Federation2016071020161542528Copyright © Гималова Г.Ф., Карунас А.С., Федорова Ю.Ю., Гуменная Э.Р., Левашева С.В., Эткина Э.И., Хуснутдинова Э.К., 20162016Гималова Г.Ф., Карунас А.С., Федорова Ю.Ю., Гуменная Э.Р., Левашева С.В., Эткина Э.И., Хуснутдинова Э.К.Gimalova G.F., Karunas A.S., Fedorova Y.Y., Gumennaya E.R., Levashova S.V., Etkina E.I., Khusnutdinova E.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medgen-journal.ru/jour/article/view/112

Атопический дерматит (АД) - хроническое воспалительное заболевание кожи, обычно проявляющееся в раннем детстве и часто предшествующее аллергическим заболеваниям. На сегодняшний день проведено несколько полногеномных анализов, выявивших ряд новых полиморфных локусов, ассоциированных с развитием АД. Нами исследованы полиморфные варианты, локализованные в хромосомной области 11q13.5 (гены C11orf30 и LRRC32 ), а также однонуклеотидные полиморфизмы генов KIF3A, OVOL1 и ACTL9. Показана ассоциация полиморфного локуса rs2508755 гена C11orf30 с развитием АД у татар.

Atopic dermatitis (AD) - chronic inflammatory skin disease, which usually arise in early childhood and often precedes allergic diseases. To date several genome-wide analysis are conducted and they revealed some new polymorphic loci that are associated with atopic dermatitis development. We investigated polymorphic variants located in the 11q13.5 chromosomal region ( C11orf30 and LRRC32 genes), and SNPs in KIF3A, OVOL1 and ACTL9 genes as well. Association of rs2508755 polymorphism of the C11orf30 gene with atopic dermatitis in Tatars was shown.

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The authors declare that there are no conflicts of interest present.